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E8512

Sigma-Aldrich

Ethylmorphine

Synonym(s):

Morphine 3-ethyl ether

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About This Item

Empirical Formula (Hill Notation):
C19H23NO3
CAS Number:
76-58-4
Molecular Weight:
313.39
EC Number:
200-970-7
MDL number:
MFCD00083327
UNSPSC Code:
12352200
PubChem Substance ID:
24894676
NACRES:
NA.77

drug control

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

storage temp.

2-8°C

SMILES string

CCOc1ccc2C[C@@H]3C4C=C[C@H](O)[C@@H]5Oc1c2[C@]45CCN3C

InChI

1S/C19H23NO3/c1-3-22-15-7-4-11-10-13-12-5-6-14(21)18-19(12,8-9-20(13)2)16(11)17(15)23-18/h4-7,12-14,18,21H,3,8-10H2,1-2H3/t12-,13+,14-,18-,19-/m0/s1

InChI key

OGDVEMNWJVYAJL-LEPYJNQMSA-N

Biochem/physiol Actions

Narcotic analgesic; antitussive

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H336

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
049K4008
107K4116
077K4072
037K4074
037K4011

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Aliaa Nabil ElMeshad et al.
AAPS PharmSciTech, 21(7), 244-244 (2020-08-29)
Ethylmorphine hydrochloride (EtM) is a derivative of morphine used as analgesic to treat severe pain in case of cancer and bone injury. This study aimed to formulate and evaluate core in cup tablets containing 2 doses of EtM, the cup
K Hedenmalm et al.
Therapeutic drug monitoring, 19(6), 643-649 (1998-01-08)
The formation of morphine from codeine and ethylmorphine is mainly mediated by the polymorphic enzyme CYP2D6. The objective of this study was to investigate whether CYP2D6 poor metabolizers (PM) and CYP2D6 extensive metabolizers (EM) would respond differently during testing for
A Wayne Jones et al.
Journal of analytical toxicology, 32(4), 265-272 (2008-04-24)
Morphine and codeine are frequently identified in blood samples from impaired drivers. But whether these opiates reflect the use of prescription analgesics or abuse of the illicit drug heroin (diacetyl morphine) is not always obvious. Opiates, either alone or together
Gyula Szucs et al.
Chemico-biological interactions, 147(2), 151-161 (2004-03-12)
Tiamulin, a diterpene antibiotic, is used for treatment of pulmonary and gastrointestinal infections in swine and poultry. Combined administration of tiamulin and ionophores (e.g. monensin) to farm animals may lead to intoxication manifested in severe clinical symptoms. Tiamulin metabolite complex
Ning Ding et al.
Bioorganic & medicinal chemistry letters, 21(12), 3531-3535 (2011-05-24)
Naphtho[2,1-α]pyrrolo[3,4-c]carbazole-5,7(6H,12H)-dione (NPCD) is known to be a very potent and selective cyclin D1-CDK4 inhibitors and could induce strong G1 phase arrest in breast tumor cell lines. In this work, the synthesis of five NPCD glycosides and their cytotoxic activities against
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