E166
Monoclonal Anti-Endothelin-1 antibody produced in mouse
clone TR.ET.48.5, purified antibody
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 μL | Check Cart for Availability | RM 3,548.00 |
About This Item
Conjugate:
unconjugated
Clone:
TR.ET.48.5, monoclonal
Application:
ICC, IHC (p), RIA, WB
Citations:
15
RM 3,548.00
Check Cart for Availability
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
TR.ET.48.5, monoclonal
species reactivity
rat, human, sheep
technique(s)
immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:250, radioimmunoassay: 1:25,000, western blot: suitable
isotype
IgG1
UniProt accession no.
1 of 1
This Item | |||
|---|---|---|---|
| antibody form purified antibody | antibody form purified immunoglobulin | antibody form purified immunoglobulin | antibody form purified immunoglobulin |
| biological source mouse | biological source mouse | biological source mouse | biological source mouse |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| clone TR.ET.48.5, monoclonal | clone polyclonal | clone M1-C4, monoclonal | clone 4F1-B7, monoclonal |
| species reactivity rat, human, sheep | species reactivity human | species reactivity human | species reactivity human |
| Gene Information human ... EDN1(1906) | Gene Information human ... EDN1(1906) | Gene Information human ... TNF(7124) | Gene Information human ... ACY1(95) |
General description
Endothelin consists of a family of potent vasoconstrictor peptides, which include four structurally related isoforms, ET-1, ET-2, ET-3 and vasointestinal contractor (VIC, β -ET)
Immunogen
endothelin-1 (ET-1) conjugated to KLH
Application
Monoclonal Anti-Endothelin-1 antibody produced in mouse is suitable for immunoblotting and immunocytochemistry.It is also suitable for radioimmunoassay (RIA) at a working dilution of 1:25,000 and for immunohistochemistry at 1:250 working dilution using formalin-fixed, paraffin-embedded tissue sections.
Biochem/physiol Actions
ET-1, a 21 amino acid peptide, is produced by vascular endothelial cells. It is a potent vasoconstrictor and plays an important role in the homeostasis of the circulatory system. It is also important in pathogenesis of cardiovascular diseases. It is also involved in contraction of airway and intestinal smooth muscle. It releases vasodilator prostaglandins and nitric oxide (NO). It also plays a role in mitogenic effects on vascular smooth muscle cells and fibroblasts, stimulation of atrial natriuretic peptide secretion from atrial cardiocytes and inhibition of renin release. ET-1 is expressed in the spinal cord and dorsal root ganglia, where it may serve as a neurotransmitter/neuromodulator.
The antibody shows little cross-reactivity to related peptides and no known cross-reactivity to non-related peptides.
Physical form
Solution in phosphate buffered saline, containing 0.05% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Aykut Gram et al.
Reproduction (Cambridge, England), 150(5), 405-415 (2015-08-05)
Luteal development is regulated by many locally produced mediators, e.g., prostaglandins and angiogenic factors. However, the role and function of vasoactive factors in the canine corpus luteum (CL) remain largely unknown. Consequently, expression of the endothelin (ET) receptors-A and -B
Leryn J Reynolds et al.
Journal of applied physiology (Bethesda, Md. : 1985), 122(1), 38-47 (2016-11-01)
Increased endothelin-1 (ET-1) and reduced endothelial nitric oxide phosphorylation (peNOS) are hypothesized to reduce insulin-stimulated blood flow in type 2 diabetes (T2D), but studies examining these links in humans are limited. We sought to assess basal and insulin-stimulated endothelial signaling
M W MacCumber et al.
Proceedings of the National Academy of Sciences of the United States of America, 87(6), 2359-2363 (1990-03-01)
We have explored the cellular loci of endothelin (ET) actions and formation in the brain, using cerebellar mutant mice as well as primary and continuous cell cultures. A glial role is favored by several observations: (i) mutant mice lacking neuronal
Hany S Abed et al.
Heart rhythm, 10(1), 90-100 (2012-10-16)
Obesity is associated with atrial fibrillation (AF); however, the mechanisms by which it induces AF are unknown. To examine the effect of progressive weight gain on the substrate for AF. Thirty sheep were studied at baseline, 4 months, and 8
Aykut Gram et al.
The Journal of reproduction and development, 63(3), 235-245 (2017-02-22)
Utero-placental (Ut-Pl) angiogenesis and blood flow are fundamental for successful outcome of pregnancy. They are controlled by numerous vasodilator and vasoconstrictor systems such as endothelins (EDNs) and the renin angiotensin system. Dogs possess an invasive type of placentation, classified as
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Instructions
Global Trade Item Number
| SKU | GTIN |
|---|---|
| E166-100UL | 04061838163165 |
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