Neurotoxic on prolonged administration or at high dosage; substrate for the serotonin transporter that releases serotonin from axon terminals by a nonexocytotic mechanism and blocks the reuptake of serotonin; inhibits tryptophan hydroxylase.
International journal of molecular sciences, 22(19) (2021-10-14)
Male sexual function in mammals is controlled by the brain neural circuits and the spinal cord centers located in the lamina X of the lumbar spinal cord (L3-L4). Recently, we reported that hypothalamic oxytocin neurons project to the lumbar spinal
The Journal of pharmacology and experimental therapeutics, 293(3), 870-878 (2000-06-28)
HEK 293 cells stably expressing the human serotonin transporter (hSERT) were grown on coverslips, preincubated with [(3)H]5-hydroxytryptamine (5-HT), and superfused. Substrates of the hSERT [e.g., p-chloroamphetamine (PCA)], increased the basal efflux of [(3)H]5-HT in a concentration-dependent manner. 5-HT reuptake blockers
Development and psychopathology, 27(1), 51-67 (2015-02-03)
Data drawn from the in-home subsample of the PROSPER intervention dissemination trial were used to investigate the moderation of intervention effects on underage alcohol use by maternal involvement and candidate genes. The primary gene examined was dopamine receptor D4 (DRD4).
To sustain the global requirements for food and renewable resources, unraveling the molecular networks underlying plant growth is becoming pivotal. Although several approaches to identify genes and networks involved in final organ size have been proven successful, our understanding remains
The American journal of clinical nutrition, 102(1), 146-154 (2015-05-15)
Several methods are used to determine dietary patterns. Hybrid methods incorporate information on nutrient intake or biological factors to extract patterns relevant to disease etiology. We explore differences between patterns derived with 2 hybrid methods with those obtained by a
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
