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B7652

Sigma-Aldrich

Betamethasone 21-phosphate disodium

≥97%

Synonym(s):

Betamethasone disodium phosphate, Betamethasone sodium phosphate

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About This Item

Empirical Formula (Hill Notation):
C22H28FNa2O8P
CAS Number:
151-73-5
Molecular Weight:
516.40
EC Number:
205-797-0
MDL number:
MFCD00200361
UNSPSC Code:
12352200
PubChem Substance ID:
24892013
NACRES:
NA.77

sterility

non-sterile

Assay

≥97%

form

powder

solubility

water: 50 mg/mL, clear to very slightly hazy, faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O

InChI

1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15-,16-,17-,19-,20-,21-,22-;;/m0../s1

InChI key

PLCQGRYPOISRTQ-LWCNAHDDSA-L

Gene Information

human ... NR3C1(2908)

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Biochem/physiol Actions

Betamethasone is used to treat neonatal respiratory distress syndrome, and psoriasis.

Diagnostic Implications

Betamethasone is a corticosteroid with anti-inflammatory and immunosuppressive abilities, used especially where water retention is undesirable. It is applied as a topical cream, ointment, lotion or gel to treat itching (e.g. from eczema). Corticosteroid used to stimulate fetal lung maturation and to decrease the incidence and mortality from intracranial hemorrhage in premature infants

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H302,H360FD,H373

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B - STOT RE 2

Target Organs

Liver,Kidney,Endocrine system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cardiovascular risk factors after antenatal exposure to betamethasone: 30-year follow-up of a randomised controlled trial
Dalziel SR, et al.
Lancet, 365(9474), 1856-1862 (2005)
Efficacy results of a 52-week, randomised, double-blind, safety study of a calcipotriol/betamethasone dipropionate two-compound product (Daivobet/Dovobet/Taclonex) in the treatment of psoriasis vulgaris
Kragballe K, et al.
Dermatology (Basel, Switzerland), 213(4), 319-326 (2006)
Tsutomu Ishihara et al.
International journal of pharmaceutics, 385(1-2), 170-175 (2009-10-20)
We have prepared polymeric nanoparticles using a blend of poly(lactic acid) and monomethoxy-polyethyleneglycol(PEG)-polylactide block copolymer along with betamethasone disodium phosphate (BP). Nanoparticles have been screened for anti-inflammatory activity using experimental rat models of inflammation. In the present study, we examined
Jun Lu et al.
Journal of chromatography. A, 1217(44), 6932-6941 (2010-09-22)
Betamethasone Sodium Phosphate and Betamethasone Acetate are the two corticosteroids active pharmaceutical ingredients (APIs) that are present in the injectable formulation, Celestone Chronodose(®) Injection. It is extremely challenging to develop a Quality Control friendly HPLC method to separate all the
Masatomo Kato et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 27(4), 353-360 (2011-05-18)
Glucocorticoids exert their actions via the glucocorticoid receptor through at least 2 intracellular mechanisms, known as transrepression and transactivation. It has been hypothesized that transrepression is the basis of their anti-inflammatory effects, whereas transactivation has been assumed to cause their
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