B1061

BN82002 hydrochloride

≥97% (HPLC), solid

• Synonym(s): 4-Dimethylamino-2-methoxy-6-((methyl-[2-(4-nitrophenyl)ethyl]amino)methyl)phenol
• Empirical Formula (Hill Notation): C₁₉H₂₅N₃O₄ · xHCl
• CAS Number: 396073-89-5
• Molecular Weight: 359.42 (free base basis)
• MDL number: MFCD08276984
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724410

Properties

• Assay: ≥97% (HPLC)
• form: solid
• color: tan
• solubility: DMSO: 10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl[H].COc1cc(cc(CN(C)CCc2ccc(cc2)[N+]([O-])=O)c1O)N(C)C

Description

Biochem/physiol Actions

BN82002 is a potent, selective, and irreversible CDC25 phosphatase family inhibitor. BN82002 displays ~20-fold greater selectivity over CD45 tyrosine phosphatase (IC₅₀ in μM = 2.4, 3.9, 6.3, 5.4, and 4.6 for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). BN82002 has been shown to delay cell cycle progression in vitro (IC₅₀ in the range of 7.2 - 32.6 μM). BN82002 reduces tumor growth in athymic mice xenografted with the human pancreatic cell MIA PaCa-2 (15 mg/kg, i.p. route).

Caution

Hygroscopic.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves