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Key Documents

AV53850

Sigma-Aldrich

Anti-ZC3H14 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-FLJ11806, Anti-MGC26892, Anti-NY-REN-37, Anti-UKp68, Anti-Zinc finger CCCH-type containing 14

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

35 kDa

species reactivity

human

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... ZC3H14(79882)

Immunogen

Synthetic peptide directed towards the N terminal region of human ZC3H14

Application

Anti-ZC3H14 antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.

Biochem/physiol Actions

ZC3H14 gene encodes a ubiquitously expressed evolutionarily conserved Cys(3)His zinc finger protein that belongs to poly(A)-binding protein family. The encoded protein plays an evolutionarily conserved role in regulating the poly(A) tail length in neurons.Poly(A)-binding proteins also impacts the gene expression by controlling mRNA stability, nuclear export, and translation.Mutation in ZC3H14 gene leads to brain disorder occur due to disrupted normal development and impairs neural function in humans and drosophila.

Sequence

Synthetic peptide located within the following region: KFPSPPLPIFLPPEPVDLGSITSSSCSLNELDNISHLLRKISADINEIKG

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Seth M Kelly et al.
RNA (New York, N.Y.), 20(5), 681-688 (2014-03-29)
The ZC3H14 gene, which encodes a ubiquitously expressed, evolutionarily conserved, nuclear, zinc finger polyadenosine RNA-binding protein, was recently linked to autosomal recessive, nonsyndromic intellectual disability. Although studies have been carried out to examine the function of putative orthologs of ZC3H14
Sara W Leung et al.
Gene, 439(1-2), 71-78 (2009-03-24)
The human ZC3H14 gene encodes an evolutionarily conserved Cys(3)His zinc finger protein that binds specifically to polyadenosine RNA and is thus postulated to modulate post-transcriptional gene expression. Expressed sequence tag (EST) data predicts multiple splice variants of both human and
Changhui Pak et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(30), 12390-12395 (2011-07-08)
Here we report a human intellectual disability disease locus on chromosome 14q31.3 corresponding to mutation of the ZC3H14 gene that encodes a conserved polyadenosine RNA binding protein. We identify ZC3H14 mRNA transcripts in the human central nervous system, and we

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