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A9402

Sigma-Aldrich

[Val5]-Angiotensin I bovine

≥97% (HPLC)

Synonym(s):

Asp-Arg-Val-Tyr-Val-His-Pro-Phe-His-Leu

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About This Item

Empirical Formula (Hill Notation):
C61H87N17O14
CAS Number:
484-43-5
Molecular Weight:
1282.45
MDL number:
MFCD00133987
UNSPSC Code:
12352200
PubChem Substance ID:
24891446

Assay

≥97% (HPLC)

form

powder

color

white

UniProt accession no.

P01017

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)C(Cc1cnc[nH]1)NC(=O)C(Cc2ccccc2)NC(=O)C3CCCN3C(=O)C(Cc4cnc[nH]4)NC(=O)C(NC(=O)C(Cc5ccc(O)cc5)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(N)CC(O)=O)C(C)C)C(C)C)C(O)=O

InChI

1S/C61H87N17O14/c1-32(2)22-46(60(91)92)75-54(85)44(25-37-28-65-30-68-37)71-53(84)42(23-35-12-8-7-9-13-35)72-56(87)47-15-11-21-78(47)59(90)45(26-38-29-66-31-69-38)74-58(89)50(34(5)6)77-55(86)43(24-36-16-18-39(79)19-17-36)73-57(88)49(33(3)4)76-52(83)41(14-10-20-67-61(63)64)70-51(82)40(62)27-48(80)81/h7-9,12-13,16-19,28-34,40-47,49-50,79H,10-11,14-15,20-27,62H2,1-6H3,(H,65,68)(H,66,69)(H,70,82)(H,71,84)(H,72,87)(H,73,88)(H,74,89)(H,75,85)(H,76,83)(H,77,86)(H,80,81)(H,91,92)(H4,63,64,67)

InChI key

HYGBEAAGLVPDGM-UHFFFAOYSA-N

Gene Information

cow ... AGT(527114)

Amino Acid Sequence

Asp-Arg-Val-Tyr-Val-His-Pro-Phe-His-Leu

Application

[Val5]-Angiotensin I is an Ang 1 peptide used in renin-angiotensin system studies.

Biochem/physiol Actions

Angiotensin I is a putative neurotransmitter. It is the precursor of angiotensin II and of angiotensin fragment 1-7, which are the hormones involved in regulation of fluid volume and the release of aldosterone.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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S Kaneko et al.
Biochemical and biophysical research communications, 126(1), 587-593 (1985-01-16)
Two fractions with high potency for reversing the inhibitory effect of Met-enkephalin on the electrically induced contractility of guinea-pig ileum have been purified from bovine brain extract. Unexpectedly, one isolated peptide was identified as [Val5]-angiotensin I and the other fraction
L G Navar et al.
American journal of hypertension, 13(1 Pt 2), 45S-54S (2000-03-11)
Because of the importance of the renin-angiotensin system in the pathophysiology of hypertension and in mediating associated alterations in renal function, angiotensin II (Ang II) AT1 receptor blockers provide a direct means of protecting against influences of excessive Ang II
Determination of renin activity in human plasma by column-switching high-performance liquid chromatography with fluorescence detection.
Miyazaki T, Kai M, Ohkura Y.
Journal of Chromatography A, 490, 43-51 (1989)

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