A4140
Aequorin from jellyfish (Aequorea sp.)
Type III, solid
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About This Item
biological source
Aequorea sp.
type
Type III
form
solid
usage
mg solid sufficient for ~200 calcium assays
composition
Protein, ~0.5% Bradford
application(s)
detection
storage temp.
−20°C
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General description
Package sizes are based on total solids content
Apoaequorin has a mol. wt. approx. 22 kDa, and contains a molecule of coelenterazine hydroperoxide as the chromophoric prosthetic group. Upon binding Ca2+, aequorin decomposes to apoaequorin, coelenteramide, and CO2, and emits light.
Biochem/physiol Actions
A bioluminescent protein; can be used to measure physiological levels of calcium in serum and subcellular organelles down to 10 μM.
Physical form
Contains buffer salts consisting mainly of sodium EDTA, pH 7.5
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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ALSUntangled no. 18: apoaequorin (Prevagen).
Amyotrophic lateral sclerosis & frontotemporal degeneration, 14(1), 78-79 (2012-10-04)
Elzbieta Hejchman et al.
The Journal of pharmacology and experimental therapeutics, 343(2), 380-388 (2012-08-16)
We found that amiodarone has potent antifungal activity against a broad range of fungi, potentially defining a new class of antimycotics. Investigations into its molecular mechanisms showed amiodarone mobilized intracellular Ca2+, which is thought to be an important antifungal characteristic
Norbert Mehlmer et al.
Journal of experimental botany, 63(4), 1751-1761 (2012-01-04)
Calcium has long been acknowledged as one of the most important signalling components in plants. Many abiotic and biotic stimuli are transduced into a cellular response by temporal and spatial changes in cellular calcium concentration and the calcium-sensitive protein aequorin
Denis Ottolini et al.
Methods in molecular biology (Clifton, N.J.), 937, 273-291 (2012-09-26)
In the last two decades the study of Ca(2+) homeostasis in living cells has been enhanced by the explosive development of genetically encoded Ca(2+)-indicators. The cloning of the Ca(2+)-sensitive photoprotein aequorin and of the green fluorescent protein (GFP) from the
Satoshi Inouye et al.
Protein expression and purification, 83(2), 205-210 (2012-04-28)
Highly purified histidine-tagged aequorin with a reactive cysteine residue (His-Cys4-aequorin) was obtained from the periplasmic space of Escherichia coli cells by nickel-chelate affinity chromatography and hydrophobic chromatography. The procedure yielded 40.3mg of His-Cys4-aequorin from 2L of cultured cells with over
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