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475R-9

Sigma-Aldrich

INSM1 (MRQ-70) Rabbit Monoclonal Antibody

clone MRQ-70, unconjugated, Cell Marque™

Synonym(s):

Insulinoma-associated protein 1

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

MRQ-70, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (475R-94)
vial of 0.1 mL concentrate Research Use Only (475R-94-RUO)
vial of 0.5 mL concentrate (475R-95)
vial of 1.0 mL concentrate (475R-96)
vial of 1.0 mL concentrate Research Use Only (475R-96-RUO)
vial of 1.0 mL pre-dilute Research Use Only (475R-97-RUO)
vial of 1.0 mL pre-dilute ready-to-use (475R-97)
vial of 7.0 mL pre-dilute ready-to-use (475R-98)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (475R-98-RUO)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

pancreas

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Related Categories

General description

Insulinoma-associated protein 1 (INSM1) is a transcriptional factor with a zinc finger DNA-binding domain that is involved in neuroendocrine cell differentiation as a transcriptional repressor1. INSM1 expression has been observed during embryonic development in the cerebellum, spinal cord, olfactory epithelium, pancreas, and gastrointestinal tract2-4; however, expression in healthy adult tissues is limited to neuroendocrine cells. INSM1 is over expressed in neuroendocrine neoplasms including carcinoids, small cell carcinomas, and neuroendocrine carcinomas. This helps in identification of neuroendocrine tumors and their distinction from other lesions, such as adenocarcinomas, which exhibit little to no INSM1 expression5-6.

Quality

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sanjay Mukhopadhyay et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 32(1), 100-109 (2018-08-30)
Recent evidence suggests a role for the nuclear marker INSM1 in the diagnosis of neuroendocrine lung neoplasms. The aim of this study was to determine the utility of INSM1 as a marker of neuroendocrine differentiation using a large series of
Mathias S Gierl et al.
Genes & development, 20(17), 2465-2478 (2006-09-05)
The pancreatic and intestinal primordia contain epithelial progenitor cells that generate many cell types. During development, specific programs of gene expression restrict the developmental potential of such progenitors and promote their differentiation. The Insm1 (insulinoma-associated 1, IA-1) gene encodes a
Lilla M Farkas et al.
Neuron, 60(1), 40-55 (2008-10-23)
Basal (intermediate) progenitors are the major source of neurons in the mammalian neocortex. The molecular machinery governing basal progenitor biogenesis is unknown. Here, we show that the zinc-finger transcription factor Insm1 (insulinoma-associated 1) is expressed specifically in progenitors undergoing neurogenic
Jason N Rosenbaum et al.
American journal of clinical pathology, 144(4), 579-591 (2015-09-20)
Neuroendocrine neoplasms (NENs) are heterogeneous neoplasms, which are sometimes malignant, although predicting metastasis is difficult. INSM1 is a transcription factor expressed transiently in embryonic neuroendocrine (NE) tissue, thought to coordinate termination of cell division with differentiation of NE and neuroepithelial
Jason N Rosenbaum et al.
Neural development, 6, 6-6 (2011-02-03)
Insm1 is a zinc-finger transcription factor transiently expressed throughout the developing nervous system in late progenitors and nascent neurons. Insm1 is also highly expressed in medulloblastomas and other neuroendocrine tumors. We generated mice lacking the Insm1 gene and used them
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