This product is to be stored in room temperature.
361593
Artemisinin
98%
Synonym(s):
Arteannuin, Qinghaosu
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100 MG
RM 532.00
About This Item
Empirical Formula (Hill Notation):
C15H22O5
CAS Number:
Molecular Weight:
282.33
MDL number:
UNSPSC Code:
12352205
PubChem Substance ID:
NACRES:
NA.79
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Quality Level
Assay
98%
form
solid
optical activity
[α]20/D +76°, c = 0.5 in methanol
mp
156-157 °C (lit.)
antibiotic activity spectrum
parasites
viruses
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
Mode of action
enzyme | inhibits
SMILES string
C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3OC4(C)CC[C@@H]1[C@@]23OO4
InChI
1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1
InChI key
BLUAFEHZUWYNDE-NNWCWBAJSA-N
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General description
Application
Artemisinin has been used:
- in drug susceptibility assays[4]
- as a standard for its quantification from artemisinin from hairy roots[5]
- to check cell viability using 3-(4, 5-dimethylthiazol-2yl)-2,5-diphenyl tetrazolium bromide (MTT) assay[6]
- as an antimalarial agent to investigate the role of autophagy-related (ATG) genes throughout the P. falciparum asexual and sexual blood stages[7]
Biochem/physiol Actions
Artemisinin (Qinghaosu), a sesquiterpene lactone, is a highly active anti-malarial (falciparum malaria) drug. Artemisinin is also an anthelmintic (parasitic worm) effective against the blood fluke, schistosomiasis.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Artemisinins: their growing importance in medicine
Krishna S, et al.
Trends in Pharmacological Sciences, 29(10), 520-527 (2008)
C J Paddon et al.
Nature, 496(7446), 528-532 (2013-04-12)
In 2010 there were more than 200 million cases of malaria, and at least 655,000 deaths. The World Health Organization has recommended artemisinin-based combination therapies (ACTs) for the treatment of uncomplicated malaria caused by the parasite Plasmodium falciparum. Artemisinin is a
Olivo Miotto et al.
Nature genetics, 45(6), 648-655 (2013-04-30)
We describe an analysis of genome variation in 825 P. falciparum samples from Asia and Africa that identifies an unusual pattern of parasite population structure at the epicenter of artemisinin resistance in western Cambodia. Within this relatively small geographic area
Antiprotozoal agents
Croft SL and Seifert K
Antibiotics and Chemotherapy, 29(10), 406-426 (2011)
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At what temperature do we store artemisinin
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Is there any expiry of this compound?
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This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment. For more information you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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In what solvents is Product 361593, Artemisinin, soluble?
1 answer-
According to the chemicals encyclopedia published by the Royal Society of Chemistry, artemisinin is expected to be soluble in most aprotic solvents and slightly soluble in oil. Sigma-Aldrich tests the solubility of this product in chloroform at 25 mg/mL. Our quality control is also able to prepare a 0.5% solution in methanol in order to measure the optical rotation.
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