S0929

Scopolamine hydrobromide

meets USP testing specifications

• Synonym(s): (−)-Scopolamine hydrobromide trihydrate, Hyoscine hydrobromide, Scopine tropate
• Empirical Formula (Hill Notation): C₁₇H₂₁NO₄ · HBr · 3H₂O
• CAS Number: 6533-68-2
• Molecular Weight: 438.31
• Beilstein: 6100669
• MDL number: MFCD00150066
• UNSPSC Code: 12352116
• PubChem Substance ID: 24899453
• NACRES: NA.21

Properties

• Agency: USP/NF; meets USP testing specifications
• Quality Level: 200
• mp: 195-199 °C (dry matter) (lit.)
• application(s): pharmaceutical (small molecule)
• SMILES string: O.O.O.Br.CN1[C@@H]2C[C@H](C[C@H]1[C@@H]3O[C@H]23)OC(=O)[C@H](CO)c4ccccc4
• InChI: 1S/C17H21NO4.BrH.3H2O/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;;;;/h2-6,11-16,19H,7-9H2,1H3;1H;3*1H2/t11-,12-,13-,14+,15-,16+;;;;/m1..../s1
• InChI key: LACQPOBCQQPVIT-SEYKEWMNSA-N
• Gene Information: human ... CHRM1(1128)

Description

Application

Scopolamine hydrobromide has been used as a muscarinic receptor antagonist:

• to reverse the cardiac effects of physostigmine in rabbit heart
• to study its effect on acoustic startle reflex (gap-PPI){148)
• to study it′s in vitro antiviral, antibacterial, and antifungal activities and cytotoxicity
• to study its effect on conditioning of lever pressing

Biochem/physiol Actions

Competitive nonselective muscarinic acetylcholine antagonist. Scopolamine-induced amnesia in laboratory animals is a commonly-used model of memory deficit.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H300 + H310 + H330
• Precautionary Statements: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves