PHR1619

Beclomethasone Dipropionate

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Beclomethasone dipropionate, 9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate
• Empirical Formula (Hill Notation): C₂₈H₃₇ClO₇
• CAS Number: 5534-09-8
• Molecular Weight: 521.04
• EC Number: 226-886-0
• MDL number: MFCD00135613
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823513
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to BP 30; traceable to Ph. Eur. B0305000; traceable to USP 1048506
• API family: beclometasone
• CofA: current certificate can be downloaded
• packaging: pkg of 1 g
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]12C
• InChI: 1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1
• InChI key: KUVIULQEHSCUHY-XYWKZLDCSA-N
• Gene Information: human ... NR3C1(2908)

Description

General description

Beclomethasone Dipropionate is a second generation anti-inflammatory corticosteroid used for the treatment of allergic rhinitis.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Beclomethasone Dipropionate may be used as a pharmaceutical secondary reference standard for the determination of the analyte in biological fluids and ear drops formulations by chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2965 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

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Safety Information

• Pictograms: GHS08
• Signal Word: Warning
• Hazard Statements: H361fd,H373
• Precautionary Statements: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2 - STOT RE 2
• Target Organs: Adrenal gland,Immune system,Bone
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable