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PHR1087

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Sulfapyridine melting point standard

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Sulfapyridine, 4-Amino-N-[2-pyridyl]benzene sulfonamide, N1-(Pyridin-2-yl)sulfanilamide

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About This Item

Empirical Formula (Hill Notation):
C11H11N3O2S
CAS Number:
144-83-2
Molecular Weight:
249.29
Beilstein:
222065
EC Number:
205-642-7
MDL number:
MFCD00038036
UNSPSC Code:
41116107
PubChem Substance ID:
329823109
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1635002

API family

sulfapyridine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

~Approximately 191 °C

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Nc1ccc(cc1)S(=O)(=O)Nc2ccccn2

InChI

1S/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14)

InChI key

GECHUMIMRBOMGK-UHFFFAOYSA-N

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General description

Certified pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Sulfapyridine melting point standard, also called Sulfapyridine, is a metabolite of sulfasalazine. It is an antibiotic and is mostly used in treating rheumatoid arthritis. Sulfapyridine is a short acting sulfonamide, which can be substituted for dapsone and it does not cause neuropathy.
Sulfapyridine Melting Point Standard also called Sulfapyridine is a metabolite of Sulfasalazine. It is an antibiotic and is mostly used in treating rheumatoid arthritis.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7140 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H361fd

Hazard Classifications

Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD3729
LRAC0584
LRAA7140
P500087

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Nature chemical biology, 7(6), 375-383 (2011-04-19)
We introduce an approach for detection of drug-protein interactions that combines a new yeast three-hybrid screening for identification of interactions with affinity chromatography for their unambiguous validation. We applied the methodology to the profiling of clinically approved drugs, resulting in
Cemalettin Alp et al.
Journal of enzyme inhibition and medicinal chemistry, 27(6), 818-824 (2011-12-23)
The inhibition of two human cytosolic carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I, II and human serum isozyme VI, with a series of tosylited aromatic amine derivatives was investigated. The K(I) ranges of compounds 1-14 and acetazolamide against hCA I
Hai Haham et al.
Environmental science & technology, 46(21), 11870-11877 (2012-10-02)
Sorption-desorption behavior of sulfapyridine was studied with three distinct soil types low in organic carbon with or without the introduction of exogenous dissolved organic matter (DOM). Experiments with bulk soils yielded sorption coefficients equivalent to those obtained with soils richer
Hee Ji Lee et al.
Xenobiotica; the fate of foreign compounds in biological systems, 42(8), 791-797 (2012-02-22)
Probiotics are live microorganisms claimed to exert beneficial effects on the host. This study investigated their effect on the metabolism and pharmacokinetics of sulfasalazine (SSZ), a drug whose efficacy depends on metabolism by azoreductase (AR) in the gut microbiota to
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