G5882
Glutaraldehyde solution
Grade I, 25% in H2O, specially purified for use as an electron microscopy fixative
Synonym(s):
Glutaric dialdehyde solution, Pentane-1,5-dial
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About This Item
Linear Formula:
OHC(CH2)3CHO
CAS Number:
Molecular Weight:
100.12
Beilstein:
605390
MDL number:
UNSPSC Code:
12352114
PubChem Substance ID:
NACRES:
NA.21
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Quality Level
type
Grade I
form
liquid
concentration
25% in H2O
technique(s)
electron microscopy: suitable (fixative)
electron microscopy: suitable
color
colorless
useful pH range
2.9
mp
-10 °C ((14 °F ))
solubility
water: soluble at 20 °C
application(s)
cell analysis
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H]C(CCCC([H])=O)=O
InChI
1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2
InChI key
SXRSQZLOMIGNAQ-UHFFFAOYSA-N
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General description
Glutaraldehyde (Glutaric dialdehyde, Pentane-1,5-dial) is an aliphatic dialdehyde widely utilized as a versatile biochemical reagent. Glutaraldehyde solutions contain both monomers and polymers with the difference in their fixation properties. Its applications include serving as a protein crosslinker, facilitating enzyme immobilization in microscopy, histochemistry, and cytochemistry. This compound acts as an amine-reactive homobifunctional crosslinker and a cell fixative before SDS-PAGE, staining, or electron microscopy, making it suitable for diverse morphological studies.
Glutaraldehyde efficiently crosslinks amine and hydrazine derivatives to proteins and other amine-containing polymers. Notably, it has been used in certain reactions to directly couple biotin hydrazides to nucleic acids, suggesting potential applications in conjugating fluorescent hydrazides and hydroxylamines to DNA. In histology studies, Glutaraldehyde is employed to preserve tissue sections, preparing them for closer examination.
Glutaraldehyde efficiently crosslinks amine and hydrazine derivatives to proteins and other amine-containing polymers. Notably, it has been used in certain reactions to directly couple biotin hydrazides to nucleic acids, suggesting potential applications in conjugating fluorescent hydrazides and hydroxylamines to DNA. In histology studies, Glutaraldehyde is employed to preserve tissue sections, preparing them for closer examination.
Application
Glutaraldehyde solution has been used:
- to fix the blood samples for scanning electron microscopy (SEM)
- to fix scaffold pieces for SEM analysis
- in drug treatments to treat K562 (leukemia) cells to permanently cross-link cell components
Biochem/physiol Actions
Glutaraldehyde can be used in biomedical research to fix cells. It can also be used as a tool to investigate healthy and pathologic red blood cells. Medical equipment like spirometry tubing, endoscopes, dialyzers, hemodialysis proportioning and dialysate delivery systems, endocavitary probes, transducers, anesthesia and respiratory therapy equipment, and reuse of laparoscopic disposable plastic trocars can be disinfected with glutaraldehyde.
Features and Benefits
- Versatile and adaptable for wide variety of research applications
- Ready-made solution reduces the need for preparation time
Other Notes
For additional information on our range of Biochemicals, please complete this form.
Recommended for techniques demanding high purity.
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
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Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
8A - Combustible corrosive hazardous materials
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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