Alternative disinfection technologies may overcome some of the limitations of conventional treatment applied in swimming pools: chlorine-resistant pathogens (e.g. Cryptosporidium oocysts and Giardia cysts) and the formation of chlorinated disinfection byproducts. In this paper, results of full scale validation of
Xenobiotica; the fate of foreign compounds in biological systems, 51(3), 316-323 (2020-11-13)
Plasma concentrations of acetaminophen, its glucuronide and sulfate conjugates, and cysteinyl acetaminophen were experimentally determined after oral administrations of 10 mg/kg in humanised-liver mice, control mice, rats, common marmosets, cynomolgus monkeys, and minipigs; the results were compared with reported human pharmacokinetic
Landfill leachate could be a significant source of emerging contaminants (ECs) and antibiotic resistance genes (ARGs) into the environment. This study provides the first information on the occurrence of selected ECs and ARGs in raw leachate from 16-year old closed
Journal of applied toxicology : JAT, 36(2), 320-329 (2015-07-23)
Cytochrome P450 (CYP) induction is a key risk factor of clinical drug-drug interactions that has to be mitigated in the early phases of drug discovery. Three-dimensional (3D) cultures of hepatocytes in vitro have recently emerged as a potentially better platform
Drug metabolism and disposition: the biological fate of chemicals, 44(3), 435-444 (2015-12-30)
In vitro models based on primary human hepatocytes (PHH) have been advanced for clearance (CL) prediction of metabolically stable compounds, representing state-of-the-art assay systems for drug discovery and development. Yet, limited cell availability and large interindividual variability of metabolic profiles
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