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59924

Sigma-Aldrich

Polysorbate 80

tested according to Ph. Eur.

Synonym(s):

TWEEN® 80, Polysorbatum 80, POE (20) sorbitan monooleate, Polyethylene glycol sorbitan monooleate, Polyoxyethylenesorbitan monooleate, Polysorbate 80

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About This Item

CAS Number:
9005-65-6
MDL number:
MFCD00082107
UNSPSC Code:
12161900
NACRES:
NA.21

Agency

USP/NF
tested according to Ph. Eur.

Quality Level

200

vapor pressure

<1 mmHg ( 20 °C)

description

non-ionic

form

liquid

mol wt

average mol wt 79,000

aggregation number

60

refractive index

n20/D 1.472 (lit.)

CMC

0.012

transition temp

cloud point 65 °C

density

1.064 g/mL at 25 °C (lit.)

HLB

15

application(s)

pharmaceutical (small molecule)

SMILES string

CCCCCCCC/C=C/CCCCCCCC(=O)OCCOCC(C1C(CC(O1)OCCO)OCCO)OCCO

InChI

1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+

InChI key

RGPBUVUVZKQNHD-MDZDMXLPSA-N

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General description

Polysorbate 80 is a surfactant. Polysorbates are a combination of oleic esters of sorbitol and sorbitanes with polyethylene glycol chains.

Application

Polysorbate 80 has been used in drug (rapamycin) treatment and to study the effect of rapamycin on osteolysis and tumor growth. It has also been used in the preparation of spray-dried emulsions and to study antibacterial efficacy.

Biochem/physiol Actions

Polysorbates is used as emulsifiers, dissolving agents and stabilizer for essential oils, topical application and medical infusions including intravenous, subcutaneous or intramuscular administration.

Legal Information

TWEEN is a registered trademark of Croda International PLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL8063
BCCL7067
BCCL4464
BCCL1438
BCCK8135

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Relationship between Polysorbate 80 solubilization descriptors and octanol-water partition coefficients of drugs
Alvarez Nunez FA and Yalkowsky SH
International Journal of Pharmaceutics, 200(2), 217-222 (2000)
Nilsel Okudan et al.
Brain research bulletin, 165, 81-89 (2020-10-04)
Statins are cholesterol lowering drugs that decrease the risk of cardiovascular events, but they are related with a few unfavorable symptoms in skeletal muscle including myopathy, and mild to moderate fatigue. Additionally, there has been discrepancies about the impacts of
Priya N O Kasimbeg et al.
Journal of pharmaceutical sciences, 108(1), 155-161 (2018-10-14)
Characterizing protein aggregates in the presence of silicone oil is a long standing challenge for the pharmaceutical industry. Silicone oil is often used as a lubricant in devices that deliver and store therapeutic protein products and has been linked to
Enhancing the antibacterial efficacy of isoeugenol by emulsion encapsulation
Nielsen CK, et al.
International Journal of Food Microbiology, 229, 7-14 (2016)
Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions
Coors EA, et al.
Annals of Allergy, Asthma & Immunology, 95(6), 593-599 (2005)
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