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47673

Sigma-Aldrich

Formaldehyde solution

tested according to Ph. Eur.

Synonym(s):

Formaldehydi solutio 35 per centum, Formalin

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About This Item

Linear Formula:
HCHO
CAS Number:
50-00-0
Molecular Weight:
30.03
Beilstein:
1209228
MDL number:
MFCD00003274
UNSPSC Code:
12352114
PubChem Substance ID:
329757334
NACRES:
NA.25

Agency

USP/NF
tested according to Ph. Eur.

Quality Level

200

vapor density

1.03 (vs air)

vapor pressure

52 mmHg ( 37 °C)

form

liquid

autoignition temp.

572 °F

contains

9.0-15.0 % (v/v) methanol as stabilizer

concentration

25-50%

solubility

water: soluble

density

1.09 g/mL at 25 °C (lit.)

suitability

suitable for manufacturing use (Laboratory chemicals)

SMILES string

[H]C([H])=O

InChI

1S/CH2O/c1-2/h1H2

InChI key

WSFSSNUMVMOOMR-UHFFFAOYSA-N

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Application

Formaldehyde solution has been used to fix labeled cells during flow cytometry.

Biochem/physiol Actions

Formaldehyde is the simplest aldehyde that denatures the bihelical regions of RNA and converts the polynucleotides into random coils. It is a genotoxic substance that significantly induces DNA-protein crosslinks (DPC), sister-chromatid exchanges, micronuclei formation and leads to cytotoxicity. It also induces tumors in the nasal epithelium of rats and supposed to be a human carcinogen.

Caution

may become turbid on storage

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Carc. 1B - Eye Dam. 1 - Flam. Liq. 3 - Muta. 2 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 1 - STOT SE 3

Target Organs

Eyes,Central nervous system, Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

133.0 °F - closed cup

Flash Point(C)

56.11 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL7378
BCCL8065
BCCL5543
BCCK8902
BCCL0858

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Formaldehyde solution min. 37% free from acid stabilized with about 10% methanol and calcium carbonate for histology

Sigma-Aldrich

1.03999

Formaldehyde solution min. 37% free from acid

J L Wilson et al.
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O Merk et al.
Environmental and molecular mutagenesis, 32(3), 260-268 (1998-11-14)
Formaldehyde (FA) is a genotoxic substance, induces tumors in the nasal epithelium of rats, and is suspected to be a human carcinogen. As a primary DNA lesion, FA induces DNA-protein crosslinks (DPC) and the formation of DPC has been used
Dependence of the sedimentation coefficient on molecular weight of RNA after reaction with formaldehyde.
H Boedtker
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