22128

Cefotaxime sodium salt

≥98.0% (TLC)

• Synonym(s): Cefotaxim sodium salt
• Empirical Formula (Hill Notation): C₁₆H₁₆N₅NaO₇S₂
• CAS Number: 64485-93-4
• Molecular Weight: 477.45
• Beilstein: 5711411
• EC Number: 264-915-9
• MDL number: MFCD00079073
• UNSPSC Code: 51101500

Properties

• Assay: ≥98.0% (TLC)
• impurities: ≤5% water
• solubility: H₂O: 50 mg/mL, clear, light yellow
• Mode of action: cell wall synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: [Na+].[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c3csc(N)n3)C([O-])=O
• InChI: 1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1
• InChI key: AZZMGZXNTDTSME-JUZDKLSSSA-M

Description

General description

Chemical structure: ß-lactam

Biochem/physiol Actions

Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.

Other Notes

Broad spectrum third generation cephalosporin antibiotic.

This product has been replaced by C7912-SIGMA | Cefotaxime sodium salt potency: 916-964 μg per mg