2106

Heparin sodium salt from porcine intestinal mucosa

endotoxin, free

• CAS Number: 9041-08-1
• MDL number: MFCD00081689
• UNSPSC Code: 12352201
• NACRES: NA.21

Properties

• biological source: Porcine intestinal mucosa
• Quality Level: 200
• form: powder
• usage: sufficient for 5 mL blood anticoagulant
• packaging: preweighed vial of 300 USP units
• impurities: endotoxin, free
• color: beige
• solubility: water: soluble 50 g/L; acetone: insoluble; alcohol: insoluble; benzene: insoluble; chloroform: insoluble; diethyl ether: insoluble
• compatibility: for use with E-Toxate^™
• storage temp.: room temp

Description

Application

Heparin sodium salt from porcine intestinal mucosa has been used as a M199 medium supplement used for maintaining human umbilical vein endothelial cells.

Biochem/physiol Actions

Heparin sodium salt is the salt form of heparinic acid and is a polymer classified as a mucopolysaccharide or a glycosoaminoglycan. It is an anticoagulant that produces its major anticoagulant effect by activating antithrombin. Heparin binds to antithrombin III, a naturally occurring plasma protease inhibitor and accelerates significantly the rate at which antithrombin III (AT-III) inhibits coagulation proteases (factor Xa and thrombin). Additionally, it also facilitates the stabilization and regulation of tryptase as an enzymatically active tetramer.

Caution

Not for injection.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Legal Information

E-Toxate is a trademark of Sigma-Aldrich Co. LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves