407721
m-Iodobenzylguanidine, Hemisulfate - CAS 80663-95-2 - Calbiochem
Synonym(s):
3-Iodobenzylguanidine, Hemisulfate, MIBG
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About This Item
Assay
≥99% (HPLC)
form
solid
color
colorless to white
solubility
H2O: 20 mg/mL
General description
A cell-permeable norepinephrine analog that displays antiproliferative and proapoptotic properties. Reported to competitively inhibit arginine-dependent mono-ADP-ribosylation, impair mitochondrial respiration, stimulate glycolysis, and prevent terminal differentiation of skeletal myoblasts reversibly. Readily taken up by tissues rich in sympathetic neurons and neuroendocrine neoplasm via norepinephrine transporters (NET). Inhibits the phosphorylation of the Rho effector, PRK1/2 with no effect on the stimulation of MAP and PI-3 kinases.
Biochem/physiol Actions
Arginine-dependent mono-ADP-ribosylation
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Storage Class Code
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
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