361562
GSK-3β Inhibitor XVIII
The GSK-3β Inhibitor XVIII, also referenced under CAS 1139875-74-3, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
GSK-3β Inhibitor XVIII, 2-(Chloro-4-(4-thiophen-2-yl-pyrimidin-2-ylamino)-phenyl)-(4-methyl-pierazin-1-yl)-methanone
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About This Item
Empirical Formula (Hill Notation):
C20H20ClN5OS
CAS Number:
Molecular Weight:
413.92
UNSPSC Code:
12352200
Quality Level
Assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable thienylpyrimidine compound that is reported to act as a potent and selective GSK-3β inhibitor (IC50 = 64 nM), while exhibiting little or no activity against 58 and much reduced potency against 7 (>75% inhibition at 5 µM) other kinases. Shown to activate cellular Wnt pathway signaling (EC50 = 1.25 µM in a Super (8X) TOPFlash reporter assay) in HEK293 cultures and promote proliferation of murine and hamster β cell lines (EC50 = 1.143 µM using murine R7T1 cultures) as well as of primary rat β cells.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Other Notes
Wang, W., et al. 2009. Proc. Natl. Acad. Sci. USA106, 1427.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Weidong Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(5), 1427-1432 (2009-01-24)
To identify small molecules that can induce beta-cell replication, a large chemical library was screened for proliferation of growth-arrested, reversibly immortalized mouse beta cells by using an automated high-throughput screening platform. A number of structurally diverse, active compounds were identified
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