1.41464

Parteck^® MXP (Polyvinyl alcohol 4-88)

EMPROVE^® ESSENTIAL, Ph. Eur., ChP, JPE, USP

• Synonym(s): Parteck^® Polyvinyl alcohol, PVA, PVOH
• Linear Formula: (C₂H₄O)_n
• CAS Number: 9002-89-5
• MDL number: MFCD00081922
• UNSPSC Code: 13111042

Properties

• Agency: ChP; JPE; Ph. Eur.; USP
• Quality Level: 500
• product line: EMPROVE^® ESSENTIAL
• form: fine powder
• particle size: ≤200 μm (d95)
• mp: 160-240 °C
• application(s): controlled release; pharmaceutical; solid formulation; solubility enhancement
• storage temp.: 15-25°C
• InChI: 1S/C2H4O/c1-2-3/h2-3H,1H2
• InChI key: IMROMDMJAWUWLK-UHFFFAOYSA-N

Description

General description

With formulation challenges in mind, we have used particle engineering technologies to develop functional excipients specifically for solid dosage forms. The products in our Parteck^® portfolio feature unique particle properties tailored for excellent performance in tableting processes, for specific drug delivery technologies, or for solubility enhancement.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Parteck^® MXP excipient is a polyvinyl alcohol-based excipient specifically designed for hot-melt extrusion to increase the solubility of poorly water soluble APIs via stabilization of the amorphous solid state. Parteck^® MXP enables stable and high drug loads and can be used for a broad range of poorly water soluble APIs and a variety of final dosage forms.

Features and Benefits

• Superior supersaturation performance via precipitation inhibition
• High thermostability up to 250°C, extending the potential application range
• Stable high drug loads and suitability with a broad range of APIs
• Flexible release kinetics
• Compatible with several downstream processing capabilities, like direct compression, continuous manufacturing, thin film extrusion and 3D printing
• Optimized powder properties for excellent performance in the HME process
• Suitable polymer properties for HME, spray drying and 3D printing processes

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1