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Key Documents

07-787

Sigma-Aldrich

Anti-phospho-Abl (Tyr245) Antibody

Upstate®, from rabbit

Synonym(s):

ABL1, JTK7, c-ABL, p150, v-abl

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, mouse, rat

manufacturer/tradename

Upstate®

technique(s)

ELISA: suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_005157.3
NM_007313.2

UniProt accession no.

P00519

shipped in

dry ice

target post-translational modification

phosphorylation (pTyr245)

Gene Information

human ... ABI1(10006)
mouse ... Abi1(11308)
rat ... Abi1(79249)

Specificity

Other species have not been tested.
Recognizes both Abl and BCR-Abl when phosphorylated on tyrosine residue corresponding to Tyr245 in Abl.

Immunogen

KLH-conjugated peptide corresponding to amino acid region encompassing human c-Abl Tyr245.

Application

Anti-phospho-Abl (Tyr245) Antibody is an antibody against phospho-Abl (Tyr245) for use in ELISA & WB.
Research Category
Signaling
Research Sub Category
Cytoskeletal Signaling

General Post-translation Modification

Quality

Routinely evaluated by immunoblot.

Target description

145 kDa (210 kDa for BCR-Abl)

Physical form

ImmunoAffinity Purified

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A common phosphotyrosine signature for the Bcr-Abl kinase
Goss, Valerie L, et al
Blood, 107, 4888-4897 (2006)
Phosphotyrosine mapping in Bcr/Abl oncoprotein using phosphotyrosine-specific immonium ion scanning
Steen, Hanno, et al
Molecular and Cellular Proteomics, 2, 138-145 (2003)
Phosphoproteomic analysis of AML cell lines identifies leukemic oncogenes
Walters, Denise K, et al
Leukemia Research, 30, 1097-1104 (2006)
Anna Stenqvist et al.
Neuroscience letters, 435(1), 11-16 (2008-03-21)
Ret is a receptor tyrosine kinase for the GDNF family of ligands and plays important roles during nervous system development for cell proliferation, cell migration and neurite growth. Signaling initiated from intracellular tyrosine 1062, by recruitment of several different phosphotyrosine

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