790528P

18:1 DGS-NTA

1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (ammonium salt), powder

• Synonym(s): 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (ammonium salt); DOGS NTA
• Empirical Formula (Hill Notation): C₅₃H₁₀₀N₅O₁₃
• CAS Number: 474942-78-4
• Molecular Weight: 1015.39
• MDL number: MFCD00057815
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 5 mg (790528P-5mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 790528P
• shipped in: dry ice
• storage temp.: −20°C

Description

General description

1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (18:1 DGS-NTA) is amphiphile.[1] DGS-NTA is a nitrilotriacetic acid -functionalized amphiphile devoid of nickel ion.[1]

Application

18:1 DGS-NTA 1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (ammonium salt) has been used:

• for generation of amphiphile monolayer [1]
• in NTA-liposome preparation for procoagulant binding studies and to study its effect on factor FXII autoactivation[2]
• as a liposome component for lipid bilayer preparation for surface plasmon resonance studies[3]

Biochem/physiol Actions

1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (18:1 DGS-NTA or DOGS-NTA) cannot bind to histidine due to lack of nickel ion. It is capable of self-assembly to form a stable monolayer.[1] DOGS-NTA ammonium salt is useful in bicelle preparation. [4]

Packaging

5 mL Clear Glass Sealed Ampule (790528P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids