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700072P

Avanti

zymosterol-d5

Avanti Research™ - A Croda Brand

Synonym(s):

(2,2,3,4,4-D5)-5α-cholesta-8,24-dien-3β-ol

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About This Item

Empirical Formula (Hill Notation):
C27H39D5O
CAS Number:
1246298-29-2
Molecular Weight:
389.67
UNSPSC Code:
12352211
NACRES:
NA.25

description

(2,2,3,4,4-d5)-zymosterol

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700072P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

SMILES string

C[C@]12CCC([C@](CC([2H])([2H])[C@@](O)([2H])C3([2H])[2H])(C)C3CC4)=C4[C@]1([H])CC[C@]2([H])[C@]([H])(C)CCC=C(C)C

General description

Zymosterol-d5 is the deuterated form of zymosterol. Zymosterol is a precursor of cholesterol and the synthesis events occur in rough endoplasmic reticulum.

Application

Zymosterol-d5 has been used as a standard in liquid chromatography–mass spectrometry (LC-MS) for quantification of sterols from human plasma samples.

Biochem/physiol Actions

Zymosterol is a substrate for 24-dehydrocholesterol reductase. It acts as a methyl acceptor and exists as fatty acid ester aerobically-grown yeast cells.

Packaging

5 mL Amber Glass Screw Cap Vial (700072P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Y Lange et al.
The Journal of biological chemistry, 266(32), 21439-21443 (1991-11-15)
Where examined, cholesterol is synthesized in the endoplasmic reticulum; however, its precursor, zymosterol, is found mostly in the plasma membrane. The novel implication of these disparate findings is that zymosterol circulates within the cell. In tracing its movements, we have
N Ariga et al.
Journal of biochemistry, 83(4), 1109-1116 (1978-04-01)
In order to identify the methyl acceptor for the methylation of sterol side-chains in ergosterol biosynthesis, Saccharomyces cerevisiae (wild type) was grown in the presence and absence of ethionine which was expected to be an inhibitor of the methylation. Gas-liquid
Jeffrey G McDonald et al.
Journal of lipid research, 53(7), 1399-1409 (2012-04-21)
We describe the development of a method for the extraction and analysis of 62 sterols, oxysterols, and secosteroids from human plasma using a combination of HPLC-MS and GC-MS. Deuterated standards are added to 200 μl of human plasma. Bulk lipids
Natalia Mast et al.
PloS one, 12(10), e0187168-e0187168 (2017-10-27)
Cytochrome P450 46A1 (CYP46A1) converts cholesterol to 24-hydroxycholesterol and thereby controls the major pathways of cholesterol removal from the brain. Cyp46a1-/- mice have a reduction in the rate of cholesterol biosynthesis in the brain and significant impairments to memory and

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