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M5801

Sigma-Aldrich

3-Mercaptopropionic acid

≥99%

Synonym(s):

3-sulfanylpropanoic acid

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5 G
RM 280.00
100 G
RM 295.00
500 G
RM 566.00

About This Item

Linear Formula:
HSCH2CH2CO2H
CAS Number:
Molecular Weight:
106.14
Beilstein:
773807
EC Number:
MDL number:
UNSPSC Code:
12352103
PubChem Substance ID:
NACRES:
NA.23

RM 280.00


Estimated to ship on15 April 2025


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vapor pressure

0.04 mmHg ( 20 °C)

Quality Level

Assay

≥99%

form

liquid

autoignition temp.

662 °F

refractive index

n20/D 1.492 (lit.)

bp

110-111 °C/15 mmHg (lit.)

mp

15-18 °C (lit.)

density

1.218 g/mL at 25 °C (lit.)

SMILES string

OC(=O)CCS

InChI

1S/C3H6O2S/c4-3(5)1-2-6/h6H,1-2H2,(H,4,5)

InChI key

DKIDEFUBRARXTE-UHFFFAOYSA-N

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General description

3-Mercaptopropionic acid (3-MPA) is used as a self-assembled monolayer (SAM) with a thiol and carboxylic groups. It has short carbon chains and is mainly used as a capping agent on a variety of nanoparticles.[1][2]

Application

3-MPA is used to produce hydrophilic SAMs, which are terminated with carboxylic acids and can be further functionalized[3] to introduce more complex end groups such as enzymes for biosensor applications.[4] SAMs of 3-MPA are capped on ZnSe quantum dots for the electrochemical detection of dopamine.[2] 3-MPA is used as a capping agent on CdTe quantum dot nanocrystals (QD NCs) for use as labeling materials in biomedical applications.[5][6] It can also be used to modify the surface of iron oxide nanoparticles (Fe2O3) in the extraction and preconcentration of Al3+ and Cr3+ ions from different biological samples.[7]

Pictograms

Skull and crossbonesCorrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 1

Flash Point(F)

200.1 °F - closed cup

Flash Point(C)

93.4 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

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Pedrosa, V. A.; Caetano, J.; Machado, S. A. S.; Freire, R. S.; Bertotti, M.
Electroanalysis, 19, 1415-1420 (2007)
Coating aqueous quantum dots with silica via reverse microemulsion method: toward size-controllable and robust fluorescent nanoparticles.
Yang Y, et al.
Chemistry of Materials, 19(17), 4123-4128 (2007)
Enhancement effect of illumination on the photoluminescence of water-soluble CdTe nanocrystals: Toward highly fluorescent CdTe/CdS core- shell structure.
Bao H, et al.
Chemistry of Materials, 16(20), 3853-3859 (2004)
A potential masking approach in the detection of dopamine on 3-mercaptopropionic acid capped ZnSe quantum dots modified gold electrode in the presence of interferences.
Ndangili PM, et al.
Journal of Electroanalytical Chemistry, 643(1-2), 77-81 (2010)
Atomic absorption spectrometric determination of Al3+ and Cr3+ after preconcentration and separation on 3-mercaptopropionic acid modified silica coated-Fe3O4 nanoparticles.
Mashhadizadeh MH and Amoli-Diva M
Journal of Analytical Atomic Spectrometry, 28(2), 251-258 (2013)

Articles

Professor Aran discusses engineering graphene-based materials through careful functionalization, enabling diverse applications.

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. Hello, In our lab, we have a chemical M5801 3-Mercaptopropionic acid, ≥99% from your company. Could you please tell us what is the molarity of this chemical and also which solvants you use to lower its molarity?

    1 answer
    1. M5801 (3-Mercaptopropionic acid) is a neat material without using any solvent. The molarity = Density x wt% x 1000 / Molecular Weight = 1.218 g/mL x 100% x 1000 / 106.14 g/mol = 11.48 mol/L. No solvent has been used to lower its molarity.

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