68193

Methyl L-3-phenyllactate

≥97.0% (HPLC)

• Synonym(s): Methyl (S)-2-hydroxy-3-phenylpropionate
• Empirical Formula (Hill Notation): C₁₀H₁₂O₃
• CAS Number: 13673-95-5
• Molecular Weight: 180.20
• MDL number: MFCD00038224
• UNSPSC Code: 12352108
• PubChem Substance ID: 57652130
• NACRES: NA.22

Properties

• Assay: ≥97.0% (HPLC)
• optical activity: [α]/D +4.4±0.5°, c = 1% in methanol
• mp: 40-45 °C (lit.)
• SMILES string: COC(=O)[C@@H](O)Cc1ccccc1
• InChI: 1S/C10H12O3/c1-13-10(12)9(11)7-8-5-3-2-4-6-8/h2-6,9,11H,7H2,1H3/t9-/m0/s1
• InChI key: NMPPJJIBQQCOOI-VIFPVBQESA-N

Description

Application

Methyl L-3-phenyllactate can be used:

• As an intermediate in the synthesis of bortezomib analogs as 20S proteasome inhibitors.
• As a substrate in the amination of the benzylic C-H bonds and the aminated products are further used to prepare β-lactams.
• As an intermediate in one of the key synthetic steps for the preparation of YM-254890 analog, a selective Gαq/11 inhibitor.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves