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Sigma-Aldrich

2-Amino-4-chlorobenzonitrile

99%

Synonym(s):

4-Chloroanthranilonitrile, 5-Chloro-2-cyanoaniline

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About This Item

Linear Formula:
H2NC6H3(Cl)CN
CAS Number:
38487-86-4
Molecular Weight:
152.58
Beilstein:
2085559
EC Number:
253-967-8
MDL number:
MFCD00035927
UNSPSC Code:
12352100
PubChem Substance ID:
24865306
NACRES:
NA.22

Assay

99%

form

powder

mp

157-162 °C (lit.)

SMILES string

Nc1cc(Cl)ccc1C#N

InChI

1S/C7H5ClN2/c8-6-2-1-5(4-9)7(10)3-6/h1-3H,10H2

InChI key

UZHALXIAWJOLLR-UHFFFAOYSA-N

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General description

2-Amino-4-chlorobenzonitrile (2A4CBN) is a benzonitrile derivative. A study of the molecular structure, vibrational spectra and NBO analysis of 2A4CBN has been undertaken. Transformation of 2A4CBN into quinazoline-2,4(1H,3H)-diones at atmospheric pressure of CO2 in the presence of monomeric tungstate, TBA2[WO4] (TBA = tetra-n-butylammonium) has been reported.

Application

2-Amino-4-chlorobenzonitrile may be used in the preparation of the following:
  • 6-chloro-4-(1-diethylamino-4-pentylamino)-2-(p-methoxyphenyl)-quinazoline dihydrochloride
  • 7-chloro-4-(1-diethylamino-4-pentylamino)-2-(p-methoxyphenyl)-quinazoline dihydrochloride
  • 4,7-dichloro-2-(2-methylprop-1-enyl)-6-nitroquinazoline
  • 6-chlorotacrine
  • N-(2-chloro-5-cyanophenyl)-4,4,4-trifluorobutanamide

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A novel hybrid of 6-chlorotacrine and metal-amyloid-β modulator for inhibition of acetylcholinesterase and metal-induced amyloid-β aggregation.
Kochi A, et al.
Chemical Science, 4(11), 4137-4145 (2013)
FT-IR and FT-Raman spectra, vibrational assignments, NBO analysis and DFT calculations of 2-amino-4-chlorobenzonitrile.
Sudha S, et al.
Journal of Molecular Structure, 958(2), 148-156 (2011)
6-(and 7-)-Chloro-4-(1-diethylamino-4-pentylamino)-2-(p-methoxyphenyl)-quinazoline Dihydrochlorides.
McKee RL, et al.
Journal of the American Chemical Society, 69(4), 940-942 (1947)
Regioselective Suzuki-Miyaura reaction: application to the microwave-promoted synthesis of 4,7-diarylquinazolines
Kabri, Y.; et al.
Molecules (Basel), 15(5), 2949-2961 (2010)
Youssef Kabri et al.
Molecules (Basel, Switzerland), 15(5), 2949-2961 (2010-07-27)
New diarylquinazolines displaying pharmaceutical potential were synthesized in high yields from 4,7-dichloro-2-(2-methylprop-1-enyl)-6-nitroquinazoline by using microwave-promoted regioselective Suzuki-Miyaura cross-coupling reactions.
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