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Merck

PDE4C

phosphodiesterase 4C, cAMP-specific

Synonyms:
DPDE1
Species:
Human PDE4C (5143), Mouse Pde4c (110385), Rat Pde4c (290646), dog PDE4C (609938), cow PDE4C (524624), domestic cat PDE4C (101086123), naked mole-rat Pde4c (101703048), sheep PDE4C (101111282)
UniProtKB ID:
Q08493, B3KTC4, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6
Gene ID:
  • Human(5143) Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
  • Mouse(110385) phosphodiesterase 4C, cAMP specific
  • Rat(290646) phosphodiesterase 4C, cAMP-specific
  • dog(609938) phosphodiesterase 4C, cAMP-specific
  • cow(524624) phosphodiesterase 4C, cAMP-specific
  • domestic cat(101086123) phosphodiesterase 4C, cAMP-specific
  • naked mole-rat(101703048) phosphodiesterase 4C, cAMP-specific
  • sheep(101111282) phosphodiesterase 4C, cAMP-specific

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Small Molecule - Antagonist

Product Number
Description
Species
PHR1023
Theophylline, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
T0800000
Theophylline, European Pharmacopoeia (EP) Reference Standard,
Species
human
1653004
Theophylline, United States Pharmacopeia (USP) Reference Standard,
Species
human
PHL82668
Theophylline, phyproof® Reference Substance,
Species
human
T1633
Theophylline, anhydrous, ≥99%, powder,
Species
mouse, human, rat

Antibodies

Product Number
Description
Species Reactivity
Application
SAB1400197
Monoclonal Anti-PDE4C antibody produced in mouse, clone 6A10, ascites fluid,
Species Reactivity
human
Application
ELISA
western blot
HPA054218
Anti-PDE4C antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
HPA048975
Anti-PDE4C antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
SAB1404183
Monoclonal Anti-PDE4C, (N-terminal) antibody produced in mouse, clone 4E5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
I0157
Ibudilast, ≥99% (HPLC), solid,
Species
human
SML0517
Amlexanox, ≥98% (HPLC),
Species
human
SML1099
Roflumilast, ≥98% (HPLC),
Species
human
D2800000
Diprophylline, European Pharmacopoeia (EP) Reference Standard,
Species
human
1231502
Dyphylline, United States Pharmacopeia (USP) Reference Standard,
Species
human

Proteins

Product Number
Description
Species
SRP0266
PDE4C1 Active human, recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE),
Species
human
SRP0265
PDE4C Active from mouse, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Species
mouse

esiRNA

Product Number
Description
Species
EMU043571
MISSION® esiRNA, targeting mouse Pde4c,
Species
mouse
EHU060201
MISSION® esiRNA, targeting human PDE4C,
Species
human