Saltar al contenido
Merck

Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty.

Molecular medicine reports (2012-04-04)
Bingbing Ma, Gangzhu Liang, Fuxian Zhang, Yizhi Chen, Huan Zhang
RESUMEN

Peripheral artery disease (PAD) may lead to a poor quality of life. Although percutaneous transluminal angioplasty (PTA) is widely used for the treatment of PAD, restenosis remains a major drawback. Hydrogen sulfide (H2S) plays potential roles in many physiological processes, such as vasodilatation and inhibition of smooth muscle cell proliferation. However, little is known regarding its role in arterial restenosis. In this study, we induced atherosclerotic-like lesions in rabbits, and we treated the rabbits with balloon angioplasty (BA) in a similar manner as PTA performed in the clinic. The rabbits were treated with sodium hydrosulfide (NaHS, a donor of H2S) or DL-propargylglycine (PPG, an inhibitor of H2S synthase). Treatment with NaHS significantly inhibited arterial restenosis following BA by reducing the intimal area and the intima/media ratio, while PPG treatment had a tendency to result in more severe restenosis. NaHS treatment significantly reduced smooth muscle cell (SMC) proliferation and elevated SMC apoptosis in the neointima. In contrast, PPG induced a significant increase in SMC proliferation. In conclusion, H2S attenuates the progression of neointimal hyperplasia and inhibits restenosis after BA. This discovery may lead to potential novel therapies, which can improve the prognosis of PAD patients.

MATERIALES
Referencia del producto
Marca
Descripción del producto

Roche
Kit de detección de muerte celular in situ, POD, sufficient for ≤50 tests
Sigma-Aldrich
DL-Propargylglycine, cystathionine γ-lyase inhibitor
Sigma-Aldrich
L-C-Propargylglycine, ≥99.0% (TLC)