T7205

Tegafur

powder

• Sinónimos: 5-Fluoro-1-(tetrahydro-2-furyl)uracil, Ftorafur, Tegafur
• Fórmula empírica (notación de Hill): C₈H₉FN₂O₃
• Número CAS: 17902-23-7
• Peso molecular: 200.17
• NACRES: NA.77
• PubChem Substance ID: 329826861
• UNSPSC Code: 12352200
• EC Number: 241-846-2
• MDL number: MFCD00012351
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• mp: 171-173 °C (lit.)
• solubility: DMSO: >50 mg/mL
• storage temp.: room temp
• SMILES string: FC1=CN(C2CCCO2)C(=O)NC1=O
• InChI: 1S/C8H9FN2O3/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13)
• InChI key: WFWLQNSHRPWKFK-UHFFFAOYSA-N

Descripción

Application

Tegafur has been used as an internal standard for the analysis of 5′DFCR (5′deoxyfluorocytidine) and 5′DFUR (5′deoxyfluorouridine) using HPLC techniques. Tegafur has also been used as an internal standard for the chromatographic assay of azidothymidine (AZT).

Biochem/physiol Actions

Tegafur is a pro-drug of 5-fluorouracil, an antimetabolite used as an antineoplastic agent. It has been used as adjuvant chemotherapy for curatively resected colorectal cancer therapy.

Preparation Note

Tegafur is soluble in DMSO at a concentration that is greater than 50 mg/ml.

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H301 + H311 + H331
• pcodes: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable