Unfortunately, solution stability studies of this product have not been performed. However, other sources state that this chemical is stable when stored at -20°C for up to 3 months. Avoid repeated freeze/thaw cycles.
Please see the link below to review the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/132/566/t4680pis.pdf
T4680
Terazosin hydrochloride
≥98% (TLC), powder
Sinónimos:
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine hydrochloride
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MXP 4,403.00
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MXP 19,198.00
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50 MG
MXP 4,403.00
250 MG
MXP 19,198.00
About This Item
Fórmula empírica (notación de Hill):
C19H25N5O4 · HCl
Número de CAS:
Peso molecular:
423.89
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Productos recomendados
Quality Level
assay
≥98% (TLC)
form
powder
color
white to off-white
solubility
H2O: soluble 19.60-20.40 mg/mL, clear, colorless to faintly yellow
methanol: 20 mg/mL, clear, colorless
ethanol: 4 mg/mL
originator
Abbott
SMILES string
Cl[H].COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4CCCO4
InChI
1S/C19H25N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H
InChI key
IWSWDOUXSCRCKW-UHFFFAOYSA-N
Gene Information
human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)
General description
Application
Terazosin hydrochloride has been used for orthogonality and similarity analysis using reversed-phase chromatographic studies5. Furthermore, terazosin has also been used for the evaluation of chemometric techniques to determine orthogonality and similarity in chromatographic methods6.
Biochem/physiol Actions
α1-adrenoceptor antagonist.
Features and Benefits
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Preparation Note
Terazosin hydrochloride is soluble in water at 19.60 - 20.40 mg/ml and yields a clear, colorless to faint yellow solution. It is also soluble in ethanol at 4 mg/ml. Furthermore, the product is soluble in methanol at 20 mg/ml, with heat as needed, and yields a clear, colorless solution.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Terazosin in the treatment of benign prostatic hyperplasia
Brawer MK, et al.
Archives of Family Medicine, 2(9), 929-929 (1993)
Terazosin
Titmarsh S and Monk JP
Drugs, 33(5), 461-477 (1987)
Acute generalized exanthematous pustulosis caused by terazosin hydrochloride.
Speck LM, et al.
J. Drugs Dermatol., 7(4), 395-397 (2008)
E Van Gyseghema et al.
Journal of chromatography. A, 1074(1-2), 117-131 (2005-06-09)
The starting point of this study was a current set of 32 chromatographic systems used to select initial conditions for method development to determine the impurity profile of a drug. The system exhibiting the best selectivity is then selected for
A G Ramage et al.
European journal of pharmacology, 294(2-3), 645-650 (1995-12-29)
The effects of i.v. infusion of the alpha1-adrenoceptor antagonists doxazosin and terazosin (2 mg kg-1 h-1) on spontaneous hypogastric, renal and inferior cardiac nerve activity, spontaneous bladder contractions, blood pressure, heart rate and femoral arterial flow were investigated separately in
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Can this product be frozen in saline solution and thawed for later use? For how long is the product stable in solution or should it be made fresh prior to use?
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