T4192

Tyrphostin SU 1498

≥98%

• Sinónimos: (E)-N-(3″-Phenylpropyl)-α-cyano-3′,5′-diisopropyl-4′-hydroxycinnamamide
• Fórmula empírica (notación de Hill): C₂₅H₃₀N₂O₂
• Número de CAS: 168835-82-3
• Peso molecular: 390.52
• MDL number: MFCD03453026
• UNSPSC Code: 12352200
• PubChem Substance ID: 24900199

Propiedades

• assay: ≥98%
• form: solid
• potency: 700 nM IC₅₀
• solubility: DMSO: soluble
• storage temp.: −20°C
• SMILES string: CC(C)c1cc(\C=C(/C#N)C(=O)NCCCc2ccccc2)cc(C(C)C)c1O
• InChI: 1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+
• InChI key: JANPYFTYAGTSIN-FYJGNVAPSA-N

Descripción

Application

Tyrphostin SU 1498 has been used as a VEGF inhibitor in mice¹.

Biochem/physiol Actions

Potent and selective inhibitor of the VEGF receptor kinase, Flk-1. Very weak inhibitor of PDGFR-kinase, EGFR-kinase and HER-2 kinase.

Preparation Note

Tyrphostin SU 1498 is soluble in DMSO.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves