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SRP8017

Sigma-Aldrich

Progranulin rat

recombinant, expressed in HEK 293 cells, FLAG® tagged, >95% (SDS-PAGE)

Sinónimos:

PEPI, Proepithelin

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About This Item

Número de CAS:
139316-59-9
Código UNSPSC:
12352202
NACRES:
NA.32

origen biológico

rat

recombinante

expressed in HEK 293 cells

etiqueta

FLAG® tagged

Ensayo

>95% (SDS-PAGE)

Formulario

lyophilized

mol peso

~65 kDa by SDS-PAGE

envase

pkg of 10 μg

fabricante / nombre comercial

Sigma-Aldrich

condiciones de almacenamiento

avoid repeated freeze/thaw cycles

impurezas

<0.1 EU/μg endotoxin, tested

color

white

Nº de acceso UniProt

P23785

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Información sobre el gen

rat ... Grn(29143)

Descripción general

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Forma física

Lyophilized from 0.2 μm-filtered solution in PBS.

Reconstitución

Reconstitute with 100 μL deionized water.

Otras notas

Signal peptide and rat progranulin (aa 1-602) are fused at the C-terminus to a FLAG®-tag.

Información legal

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
KP110930-1

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Lorenz Thurner et al.
Digestive diseases and sciences, 59(8), 1733-1742 (2014-03-05)
Recently, we identified neutralizing autoantibodies against progranulin (PGRN) in a wide spectrum of rheumatic diseases including cases with enteropathic spondylarthritis. PGRN is a secreted protein with strong anti-inflammatory effects, believed to be mediated by the direct inhibition of TNF receptors
Masato Kanazawa et al.
Brain : a journal of neurology, 138(Pt 7), 1932-1948 (2015-04-04)
In the central nervous system, progranulin, a glycoprotein growth factor, plays a crucial role in maintaining physiological functions, and progranulin gene mutations cause TAR DNA-binding protein-43-positive frontotemporal lobar degeneration. Although several studies have reported that progranulin plays a protective role
Michael J Smout et al.
PLoS pathogens, 11(10), e1005209-e1005209 (2015-10-21)
Infection with the human liver fluke Opisthorchis viverrini induces cancer of the bile ducts, cholangiocarcinoma (CCA). Injury from feeding activities of this parasite within the human biliary tree causes extensive lesions, wounds that undergo protracted cycles of healing, and re-injury

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