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SRP6284

Sigma-Aldrich

Irisin human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Sinónimos:

FNDC5 (cleaved), Fibronectin Type III Domain-containing Protein 5, Fibronectin Type III Repeat-containing Protein 2 (cleaved)

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About This Item

UNSPSC Code:
12352202

biological source

human

recombinant

expressed in E. coli

assay

≥95% (SDS-PAGE)

form

lyophilized powder

mol wt

~13 kDa

packaging

pkg of 10 μg

UniProt accession no.

Q8NAU1

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... FNDC5(252995)

General description

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin is cleaved from the type I membrane protein FNDC5 (fibronectin type III domain containing 5). FNDC5 is mainly expressed in the muscles. Low levels of the mRNA are also present in the kidney, liver and lung. The gene FNDC5 is mapped to human chromosome 1p35.1.

Biochem/physiol Actions

Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin) and improves systemic metabolism by increasing energy expenditure. It is mainly responsible for the conversion of white fat into brown fat. This conversion enhances metabolic uncoupling and caloric expenditure. Irisin is always associated with beneficial responses of exercise on cellular metabolism. In obese and type 2 diabetic patients, low levels of circulating irisin are characteristic of the adipose tissue and muscle.

Physical form

Lyophilized from PBS.

Reconstitution

Reconstitute to 0.1 mg/mL with 100μL sterile water.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Gianluca Vadalà et al.
Cells, 9(6) (2020-06-21)
Physical exercise favors weight loss and ameliorates articular pain and function in patients suffering from osteoarthritis. Irisin, a myokine released upon muscle contraction, has demonstrated to yield anabolic effects on different cell types. This study aimed to investigate the effect
FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise.
Huh JY, et al.
Metabolism, Clinical and Experimental, 61, 1725-1725 (2012)
Endre Kristóf et al.
Experimental cell research, 377(1-2), 47-55 (2019-02-23)
Brown and beige adipocytes contribute significantly to the regulation of whole body energy expenditure and systemic metabolic homeostasis not exclusively by thermogenesis through mitochondrial uncoupling. Several studies have provided evidence in rodents that brown and beige adipocytes produce a set
Rujun Zeng et al.
Bioscience trends, 12(6), 580-586 (2019-01-25)
Irisin is a myokine secreted from the cleavage of fibronectin type III domain-containing protein 5 (FNDC5) and has an effect on bone formation. There are limited studies about the structure of irisin and its functional unit. In order to clarify
Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity.
Staiger H, et al.
PLoS ONE, 8, e61903-e61903 (2013)
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