SRP5362

LMTK3, GST tagged from mouse

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Sinónimos: AATYK3, MGC90743
• Código UNSPSC: 12352202
• NACRES: NA.32

Propiedades

• recombinante: expressed in baculovirus infected Sf9 cells
• Ensayo: ≥70% (SDS-PAGE)
• Formulario: buffered aqueous glycerol solution
• mol peso: ~75 kDa
• Nº de acceso NCBI: NM_001005511
• Condiciones de envío: dry ice
• temp. de almacenamiento: −70°C
• Información sobre el gen: mouse ... Lmtk3(381983)

Descripción

Descripción general

LMTK3, or Lemur tyrosine kinase 3, belongs to the LMR subfamily of tyr protein kinases. LMTK3 decreases the activity of protein kinase C (PKC) and also leads to phosphorylation of AKT (Ser473), thereby increasing binding of forkhead box O3 (FOXO3) to the ESR1 promoter. LMTK3 phosphorylates ER alpha, protecting it from proteasomal degradation in vitro. Knockdown of LMTK3 leads to a reduction of tumor volume in an orthotopic mouse model and abrogates proliferation of ER alpha+ but not ER alpha- cells, indicative of its role in ER alpha activity. These findings reveal LMTK3 as a new therapeutic target for breast cancer.

Forma física

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Nota de preparación

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable