SRP5346

CyclinC, GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Sinónimos: CCNC, CycC
• Código UNSPSC: 12352202
• NACRES: NA.32

Propiedades

• recombinante: expressed in baculovirus infected Sf9 cells
• Ensayo: ≥70% (SDS-PAGE)
• Formulario: buffered aqueous glycerol solution
• mol peso: ~55 kDa
• Nº de acceso NCBI: NM_005190
• Condiciones de envío: dry ice
• temp. de almacenamiento: −70°C
• Información sobre el gen: human ... CCNC(892)

Descripción

Descripción general

Cyclin C is a member of the cyclin family of proteins. The gene encoding it is localized on human chromosome 6q16.2.[1]

Acciones bioquímicas o fisiológicas

Cyclin C interacts with the cyclin-dependent kinase 8 (CDK8)[2] and induces the phosphorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The mRNA levels of Cyclin C fluctuate during the cell cycle and peak at the G1 phase. Cyclin C acts as a critical regulator of the G0/G1 transition of human hematopoietic stem cells.[3] Cyclin C can also associate with CDK3 to enhance retinoblastoma phosphorylation at S807/811 during the G0/G1 transition,[4] and this phosphorylation is required for cells to exit G0 efficiently.

Forma física

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Nota de preparación

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable