SRP4121
IGF-I from rat
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Sinónimos:
IGF-I, IGF1, IGFIA, Somatomedin C
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About This Item
Productos recomendados
origen biológico
rat
recombinante
expressed in E. coli
Ensayo
≥95% (HPLC)
≥95% (SDS-PAGE)
Formulario
lyophilized
mol peso
~7.69 kDa
envase
pkg of 20 μg
condiciones de almacenamiento
avoid repeated freeze/thaw cycles
impurezas
endotoxin, tested
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
rat ... Igf1(24482)
Descripción general
IGF-I (insulin-like growth factor-I) is a member of a family of polypeptide growth factors. Rat IGF-I is a 7.69kDa protein containing 70 amino acid residues.
IGF-I exists in two isoforms (IGF1A and IGF1B) in mouse due to alternative transcription.[1]
Aplicación
IGF-I (Insulin-like Growth Factor-I) from rat has been used to study the the effect of IGF-I, IL-27 (interleukin-27) and IL-35 on the blood flow in the inflamed joints of rats.[2]
IGF-I from rat has also been used to test its effect on the expression of its receptor in rheumatoid arthritis model.[3]
Acciones bioquímicas o fisiológicas
IGF-I (Insulin-like growth factor-I) is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It mainly mediates growth and development. IGF-I is required for fetal growth and development.[4] It is also involved in the growth and repair of heart tissues.[5] IGF-I has been linked to neuroplasticity and hippocampal neurogenesis.[6] It is important in the recovery from ischaemic injury.[7]
IGF-I interacts with interleukins IL-27 and IL-35 and may play a role in chronic joint inflammation.[3]
Forma física
Lyophilized without additives.
Reconstitución
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Los clientes también vieron
Elham Abdi et al.
Iranian journal of immunology : IJI, 15(1), 14-27 (2018-03-20)
IGF-1 and certain other cytokines have been shown to exert inflammatory/anti-inflammatory roles in chronic joint diseases. To assess the effect of IGF-1, IL-27 and IL-35, their interaction and their receptor expression in a rheumatoid arthritis model. Freund's adjuvant-induced chronic joint
The effect of interleukins 27 and 35 and their role on mediating the action of insulin Like Growth Factor -1 on the inflammation and blood flow of chronically inflamed rat knee joint.
Houshmandi N
Cytokine, 81, 117-126 (2016)
Glucose metabolism and hepatic Igf1 DNA methylation are altered in the offspring of dams fed a low-salt diet during pregnancy.
Siqueira FR
Physiology & Behavior, 154, 68-75 (2016)
Stefano Schiaffino et al.
Skeletal muscle, 1(1), 4-4 (2011-07-30)
A highly conserved signaling pathway involving insulin-like growth factor 1 (IGF1), and a cascade of intracellular components that mediate its effects, plays a major role in the regulation of skeletal muscle growth. A central component in this cascade is the
Aimee J Varewijck et al.
European journal of endocrinology, 173(2), 119-127 (2015-05-08)
Previously we demonstrated that IGF1 receptor stimulating activity (IGF1RSA) offers advantages in diagnostic evaluation of adult GH deficiency (GHD). It is unknown whether IGF1RSA can be used to monitor GH therapy. To investigate the value of circulating IGF1RSA for monitoring
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