Human ring finger protein 20, or RNF20 (GenBank Accession No. NM_019592) full length, amino acids 2-975 (end) with N-terminal His-Flag-tag, MW=115 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Forma física
Formulated in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 ng/uL Flag peptide, 20% glycerol and 3 mM DTT.
The DNA damage response (DDR) is emerging as a vast signaling network that temporarily modulates numerous aspects of cellular metabolism in the face of DNA lesions, especially critical ones such as the double strand break (DSB). The DDR involves extensive
hBRE1/RNF20 is the major E3 ubiquitin ligase for histone H2B. RNF20 depletion causes a global reduction of monoubiquitylated H2B (H2Bub) levels and augments the expression of growth-promoting, pro-oncogenic genes. Those genes reside preferentially in compact chromatin and are inefficiently transcribed
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