PKR (GenBank Accession No. NM_181871) full length, amino acids 2-543 (end) with N-terminal His-tag, MW=59 kDa, expressed in an E. coli expression system.
Treatment of murine myotubes with high glucose concentrations (10 and 25 mM) stimulated protein degradation through the ubiquitin-proteasome pathway, and also caused activation (autophosphorylation) of PKR (double-stranded-RNA-dependent protein kinase) and eIF2alpha (eukaryotic initiation factor 2alpha). Phosphorylation of PKR and eIF2alpha
Neurobiology of aging, 29(8), 1160-1166 (2007-04-11)
Sporadic Alzheimer's disease (AD) appears to be the consequence of the interaction between combinations of genes and environmental factors (for example virus infections). To test this hypothesis, we are examining human genes relevant to herpes simplex virus type 1 (HSV-1)
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