SRP0375

LOXL2 human

recombinant, expressed in FreeStyle^™ 293-F cells, ≥86% (SDS-PAGE)

• Sinónimos: LOR2, WS9-14, lysyl oxidase-like 2
• UNSPSC Code: 12352202
• NACRES: NA.32

Propiedades

• biological source: human
• recombinant: expressed in FreeStyle^™ 293-F cells
• assay: ≥86% (SDS-PAGE)
• form: aqueous solution
• mol wt: 85 kDa
• packaging: pkg of 10 μg
• storage condition: avoid repeated freeze/thaw cycles
• concentration: 0.23 mg/mL
• NCBI accession no.: NM_002318
• UniProt accession no.: Q9Y4K0
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... LOXL2(4017)

Descripción

General description

Human LOXL2 (GenBank Accession No. NM_002318), amino acids 26 – 774 (end) with C-terminal His tag, MW = 85 kDa, expressed in FreeStyle 293-F cells.

Lysyl oxidase like 2 (LOXL2) is part of the LOX family of proteins. It is widely expressed. The gene encoding this protein is localized on human chromosome 8p21.3. It has a conserved carboxy-terminal region with a catalytic function and a divergent amino-terminal region.[1][2][3]

Biochem/physiol Actions

Lysyl oxidase like 2 (LOXL2) is an amino oxidase.[3] LOXL2 is involved in various cellular events such as gene transcription, cell migration, adhesion and differentiation.[3] The protein has a role in connecting collagen and/or elastin in the extracellular matrix.[4] It deaminates trimethylated lysine 4 in histone H3, causing transcriptional repression. LOXL2 suppresses some TFIID (transcription factor IID)-associated genes by oxidising methylated TAF10 (TATA-box binding protein associated factor 10).[5] The LOXL2 gene is upregulated in various cancers, such as gastric cancer, breast cancer and squamous cell carcinomas. The gene is associated with cancer cell invasion and lymph node metastasis.[6]

Physical form

Formulated in 8 mM PBS, pH 7.4, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, and 20% glycerol.

Legal Information

FreeStyle is a trademark of Invitrogen Corp.

Información de seguridad

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H315,H319,H360D
• pcodes: P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable