Human F-Box Protein 11 (FBXL11), also known as KDM2A, Ndy2, and JHDM1A GenBank Accession # NM_012308, a.a. 2-700 with N-terminal FLAGAvi- tag, MW = 82 kDa, expressed in Sf9 cells via a baculovirus expression system.
Aplicación
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Nota de análisis
Specific Activity: 0.01 pmole/min/μg using BPS Bioscience FBXL11 Homogeneous Assay Kit (Cat. No. 50611)
In higher eukaryotes, up to 70% of genes have high levels of nonmethylated cytosine/guanine base pairs (CpGs) surrounding promoters and gene regulatory units. These features, called CpG islands, were identified over 20 years ago, but there remains little mechanistic evidence
The rate-limiting step in ribosome biogenesis is the transcription of ribosomal RNA, which is controlled by environmental conditions. The JmjC enzyme KDM2A/JHDM1A/FbxL11 demethylates mono- and dimethylated Lys 36 of histone H3, but its function is unclear. Here, we show that
Heterochromatin plays an essential role in the preservation of epigenetic information, the transcriptional repression of repetitive DNA elements and inactive genes, and the proper segregation of chromosomes during mitosis. Here we identify KDM2A, a JmjC-domain containing histone demethylase, as a
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