SRP0311
HDAC6 H611A human
recombinant, expressed in baculovirus infected Sf9 cells, ≥79% (SDS-PAGE)
Sinónimos:
HD6, JM21, histone deacetylase 6
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Seleccione un Tamaño
50 μG
MXP 10,752.00
Seleccione un Tamaño
Cambiar Vistas
50 μG
MXP 10,752.00
About This Item
Código UNSPSC:
12352200
NACRES:
NA.32
Productos recomendados
origen biológico
human
recombinante
expressed in baculovirus infected Sf9 cells
Ensayo
≥79% (SDS-PAGE)
Formulario
aqueous solution
mol peso
161 kDa
envase
pkg of 50 μg
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
Información sobre el gen
human ... HDAC6(10013)
Descripción general
HDAC6 (histone deacetylase 6) belongs to the HDAC family of proteins. HDACs are responsible for deacetylation of nuclear histone and nonhistone proteins, including transcription factors.[1] The mutation H611A results in catalytically inactive HDAC6.[2]
Human HDAC6 with H611A mutation (GenBank Accession No. NM_006044), full length with N-terminal GST tag, MW= 161kDa, expressed in a Baculovirus expression system.
Human HDAC6 with H611A mutation (GenBank Accession No. NM_006044), full length with N-terminal GST tag, MW= 161kDa, expressed in a Baculovirus expression system.
Acciones bioquímicas o fisiológicas
HDAC6 (histone deacetylase 6) is involved in the control of microtubules, growth factor-mediated chemotaxis, stress response in presence of misfolded protein and tumor invasion. It also participates in EGF (epidermal growth factor)-mediated β-catenin nuclear presence and activation of c-myc. In mouse model, HDAC6 is implicated in oncogene-induced tumorigenesis.[3] HDAC6 is the main deacetylase for α-tubulin and thus, is involved in cell motility.[4][5] It is also involved in the formation of SGs (stress granules) and SG proteins.[5] Mutations in the 3′-UTR of the HDAC6 gene suppresses hsa-miR-433-mediated post-transcriptional regulation. This results in overexpression of HDAC6, thereby causing X-linked chondrodysplasia.[6]
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Elija entre una de las versiones más recientes:
Certificados de análisis (COA)
Lot/Batch Number
¿No ve la versión correcta?
Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
HDAC11 is a novel drug target in carcinomas.
Deubzer HE, et al.
International Journal of Cancer. Journal International Du Cancer, 132, 2200-2200 (2013)
Jiaqi Liu et al.
Journal of translational medicine, 14, 7-7 (2016-01-10)
Histone deacetylase (HDAC) inhibitors are widely used in clinical investigation as novel drug targets. For example, panobinostat and vorinostat have been used to treat patients with melanoma. However, HDAC inhibitors are small-molecule compounds without a specific target, and their mechanism
Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes.
Hook SS, et al.
Proceedings of the National Academy of Sciences of the USA, 99, 13425-13425 (2002)
Loss of a-Tubulin Acetylation Is Associated with TGF-?-induced Epithelial-Mesenchymal Transition.
Gu S, et al.
The Journal of Biological Chemistry, 291, 5396-5396 (2016)
Li S. et al.
Neurology, 41, 112-116 (2010)
Active Filters
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico
