SRP0290
Cathepsin F Active human
recombinant, expressed in FreeStyle™ 293-F cells, ≥90% (SDS-PAGE)
Sinónimos:
CATSF, CLN13
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Seleccione un Tamaño
50 μG
MXP 13,648.00
Seleccione un Tamaño
Cambiar Vistas
50 μG
MXP 13,648.00
About This Item
Productos recomendados
recombinante
expressed in FreeStyle™ 293-F cells
Ensayo
≥90% (SDS-PAGE)
Formulario
aqueous solution
actividad específica
≥18 pmol/min-μg
mol peso
53 kDa
técnicas
activity assay: suitable
solubilidad
soluble
water: soluble
Nº de acceso NCBI
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
Información sobre el gen
human ... CTSF(8722)
Descripción general
Research area: CELL SIGNALING
Human cathepsin F (GenBank Accession No. NM_003793), CD33 signal peptide(amino acids 1-16) + cathepsin S (amino acids 20-end), with C-terminal HIS tag, MW = 53 kDa (more than 58 kDa after post-modification), expressed in FreeStyle 293-F cells.
Human cathepsin F (GenBank Accession No. NM_003793), CD33 signal peptide(amino acids 1-16) + cathepsin S (amino acids 20-end), with C-terminal HIS tag, MW = 53 kDa (more than 58 kDa after post-modification), expressed in FreeStyle 293-F cells.
Aplicación
Active human cathepsin F is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Active human cathepsin F has been used in a study to assess its implications for the development of novel immunomodulators. [1] Active human cathepsin F has also been used in a study to investigate microarray expression analysis and identification of serum biomarkers for Niemann-Pick disease. [2]
Acciones bioquímicas o fisiológicas
Cathepsin F (CtsF) are endopeptidases that play a role in lysosomal protein degradation. Beyond its involvement in protein recycling, CtsF has also been associated with immune responses mediated by Toll-like receptors (TLRs) and antigen processing.[3] Additionally, mutation in the cathepsin F gene is related to the development of familial papillary thyroid cancer [4], type B Kufs disease, defective lysosomal degradation and abnormal autophagy, and Alzheimer′s disease.[5]
Definición de unidad
One unit is defined as the amount of enzyme that will cleave 1 pmol of substrate per min at 37°C
Forma física
Formulated in 45 mM sodium acetate, 135 mM NaCl and 10% glycerol.
Nota de preparación
Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.
Información legal
FreeStyle is a trademark of Invitrogen Corp.
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Elija entre una de las versiones más recientes:
Certificados de análisis (COA)
Lot/Batch Number
¿No ve la versión correcta?
Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Salma Teimoori et al.
Parasitology international, 66(4), 443-447 (2016-05-04)
Diagnosis of Opisthorchis viverrini infection by conventional stool examination is increasingly difficult due to the low intensity of the infection after several rounds of control programmes in endemic regions as well as coinfections with intestinal flukes. Therefore sensitive and specific
The Crystal Structure of Human Cathepsin F and Its Implications for the Development of Novel Immunomodulators
Somoza JR, Palmer JT, Ho JD.
Journal of Molecular Biology, 322(3), 559-568 (2012)
Celine V M Cluzeau et al.
Human molecular genetics, 21(16), 3632-3646 (2012-05-24)
Niemann-Pick disease type C (NPC) is a lysosomal storage disorder characterized by liver disease and progressive neurodegeneration. Deficiency of either NPC1 or NPC2 leads to the accumulation of cholesterol and glycosphingolipids in late endosomes and early lysosomes. In order to
Cathepsin F genetic mutation is associated with familial papillary thyroid cancer
Wang Y, et al.
Journal of Separation Science, 364(4), 414-424 (2022)
Cathepsins and their involvement in immune responses
Sebastien Conus and Hans-Uwe Simon
Swiss Medical Weekly, 140 (2010)
Active Filters
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico
