SML3365

MZ1

≥98% (HPLC)

• Sinónimos: (2S,4R)-1-((2S)-2-tert-Butyl-17-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecane)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, (2S,4R)-1-((S)-1-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-17,17-dimethyl-2,14-dioxo-6,9,12-trioxa-3,15-diazaoctadecanecarbonyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, (4R)-N-[14-[(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3,6,9-trioxa-12-azatetradec-1-yl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide, MZ 1, MZ 1 (PROTAC)
• Fórmula empírica (notación de Hill): C₄₉H₆₀ClN₉O₈S₂
• Número CAS: 1797406-69-9
• Peso molecular: 1002.64
• UNSPSC Code: 51111800
• NACRES: NA.77
• MDL number: MFCD30742945
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: -10 to -25°C
• SMILES string: O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC(COCCOCCOCCNC(C[C@H]2C3=NN=C(N3C4=C(C(C5=CC=C(C=C5)Cl)=N2)C(C)=C(S4)C)C)=O)=O)=O)NCC6=CC=C(C=C6)C7=C(N=CS7)C
• InChI key: PTAMRJLIOCHJMQ-PYNGZGNASA-N

Descripción

Biochem/physiol Actions

BRD4 degrader

MZ1 is a BRD4 degrader composed of pan-BET selective bromodomain inhibitor and the E3 ubiquitin ligase VHL ligand that induces preferential degradation of BRD4 over BRD2 and BRD3. MZ1exhibits antiproliferative effects in AML colorectal cancer cells lines.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable