Vildagliptin is soluble in a variety of solvents, both aqueous and organic. The solubility of this product is tested in DMSO with typical rates ranging from 30 – 50 mg/mL. External sources also report that this material is soluble in water and ethanol at >90 mg/mL (with sonication) as well as PBS, pH 7.2, at 10 mg/mL. This information has not been validated. Should DMSO be the solvent of choice, the final concentration should not exceed 0.01%.
SML2302
Vildagliptin
≥98% (HPLC), dipeptidyl peptidase 4 inhibitor, powder
Sinónimos:
Vildagliptin, (2S)-1-[[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2-pyrrolidinecarbonitrile, LAF-237, NVP-LAF237, (S)-1-(((1R,3R,5R,7S)-3-hydroxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile
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| Talla/SKU | Disponibilidad | Precio |
|---|---|---|
50 mg | Comprobar disponibilidad del carrito | MXP 2,027.00 |
250 mg | Comprobar disponibilidad del carrito | MXP 8,032.00 |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C17H25N3O2
Número CAS:
Peso molecular:
303.40
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Servicio técnico
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Permítanos ayudarleNombre del producto
Vildagliptin, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -81 to -91°, c = 0.1 in methanol
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
N#C[C@H]1N(CCC1)C(CN[C@@](C[C@]2([H])C3)(C[C@@](C2)([H])C4)C[C@@]34O)=O
InChI
1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12-,13+,14-,16+,17-/m0/s1
InChI key
SYOKIDBDQMKNDQ-NHMCJKAESA-N
Application
Vildagliptin has been used:
- as a dipeptidyl peptidase-4 (DPP4) inhibitor to study its effects on endoplasmic reticulum (ER) pathway under diabetic conditions
- in pharmacological inhibition to investigate the kinetics of transposable element (TE) desilencing and confirm its dependence on DPF-3 (a P-granule-localized N-terminal dipeptidase) enzymatic activity
- to study its electrochemical properties and determination in biological fluid and drug forms
Biochem/physiol Actions
Vildagliptin ia a selective inhibitor of dipeptidyl peptidase 4 (DPP4). This enzyme breaks down the incretins GLP-1 and GIP, gastrointestinal hormones that are released in response to a meal. By preventing GLP-1 and GIP inactivation, GLP-1 and GIP are able to potentiate the secretion of insulin and suppress the release of glucagon by the pancreas.
Vildagliptin may participate in lipid metabolism. It plays a key role in attenuating postprandial hypertriglyceridemia, reducing serum triglycerides, apolipoprotein B, and blood total cholesterol levels. Vildagliptin is used in diabetes mellitus type 2 (DM2) therapy and may also possess vasculoprotective properties. Vildagliptin also helps to improve mitochondrial dysfunction caused by diabetes.
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Este artículo | |
|---|---|
| description ≥98% (HPLC) | description pharmaceutical analytical impurity (PAI) |
| form powder | form - |
| assay ≥98% (HPLC) | assay - |
| storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 2 mg/mL, clear | solubility - |
| color white to beige | color - |
| optical activity [α]/D -81 to -91°, c = 0.1 in methanol | optical activity - |
Clase de almacenamiento
11 - Combustible Solids
WGK
WGK 3
Punto de inflamación (°F)
Not applicable
Punto de inflamación (°C)
Not applicable
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What is dissolving medium for this product? DMSO? or Ethanol, PBS I want to use for the cells cultured (Primary), but I'm worried about the toxicity of DMSO
1 answer-
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