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Merck
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SML0797

Sigma-Aldrich

Flibanserin

≥98% (HPLC)

Sinónimos:

1,3-Dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2H-benzimidazol-2-one, BIMT 17, BIMT 17BS

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About This Item

Fórmula empírica (notación de Hill):
C20H21F3N4O
Número de CAS:
167933-07-5
Peso molecular:
390.40
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C20H21F3N4O/c21-20(22,23)15-5-7-16(8-6-15)26-12-9-25(10-13-26)11-14-27-18-4-2-1-3-17(18)24-19(27)28/h1-8H,9-14H2,(H,24,28)

InChI key

CCIZQGRSEAHATK-UHFFFAOYSA-N

Biochem/physiol Actions

Flibanserin is a 5-HT1A receptor agonist and 5-HT2A receptor antagonist. Flibanserin has high affinity for human 5-HT1A receptors (Ki = 1 nm) and lower affinity for 5-HT2A (Ki = 49 nm) and D4 (Ki = 4–24 nm) receptors, and negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin was investigated as a novel, non-hormonal treatment for pre-menopausal women with Hypoactive Sexual Desire Disorder (HSDD). Flibanserin. Recently, Flibanserin was found to reduce L-DOPA-induced dyskinesia in a model of Parkinson′s Disease.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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John Thorp et al.
The journal of sexual medicine, 9(3), 793-804 (2012-01-14)
Hypoactive Sexual Desire Disorder (HSDD) is characterized by low sexual desire that causes marked distress or interpersonal difficulty. To assess the efficacy and tolerability of flibanserin, a postsynaptic 5-HT1A agonist/5-HT2A antagonist, in the treatment of premenopausal women with HSDD. North
Drug for low sexual desire carries significant harms, FDA advisers find.
Ray Moynihan
BMJ (Clinical research ed.), 341, c3339-c3339 (2010-07-09)
Leonard R Derogatis et al.
The journal of sexual medicine, 9(4), 1074-1085 (2012-01-18)
Hypoactive sexual desire disorder (HSDD) is the most common form of female sexual dysfunction and is characterized by low sexual desire that causes distress. The aim of this study was to assess the efficacy and safety of flibanserin, a postsynaptic
Dysfunctional women remain unsexed.
Michael G Wyllie
BJU international, 106(3), 431-432 (2010-07-27)
Boehringer Ingelheim withdraws libido drug for women.
Jeanne Lenzer
BMJ (Clinical research ed.), 341, c5701-c5701 (2010-10-14)
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