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SML0349

Sigma-Aldrich

Neferine

≥98% (HPLC)

Sinónimos:

(-)-Neferine, 4′′-O-Methylliensinine, 4-[[(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]-phenol, Methylliensinine, Neferin

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5 MG
MXP 2,358.00
25 MG
MXP 9,203.00

MXP 2,358.00

Fecha estimada de envío25 de marzo de 2025

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5 MG
MXP 2,358.00
25 MG
MXP 9,203.00

About This Item

Fórmula empírica (notación de Hill):
C38H44N2O6
Número de CAS:
2292-16-2
Peso molecular:
624.77
MDL number:
MFCD22416529
UNSPSC Code:
12352200
PubChem Substance ID:
329825352
NACRES:
NA.77

MXP 2,358.00

Fecha estimada de envío25 de marzo de 2025

Solicitar un pedido a granel

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -34 to -44° (c=0 3. CHCl3)

storage condition

desiccated
protect from light

color

white to beige

solubility

DMSO: >15 mg/mL

storage temp.

2-8°C

SMILES string

COc1ccc(C[C@H]2N(C)CCc3cc(OC)c(Oc4cc(C[C@@H]5N(C)CCc6cc(OC)c(OC)cc56)ccc4O)cc23)cc1

InChI

1S/C38H44N2O6/c1-39-15-14-27-21-36(44-5)38(23-30(27)31(39)17-24-7-10-28(42-3)11-8-24)46-34-19-25(9-12-33(34)41)18-32-29-22-37(45-6)35(43-4)20-26(29)13-16-40(32)2/h7-12,19-23,31-32,41H,13-18H2,1-6H3/t31-,32+/m1/s1

InChI key

MIBATSHDJRIUJK-ZWXJPIIXSA-N

Application

Neferine has been used to study its effect in autophagy signalling.[1]

Biochem/physiol Actions

Neferine is a bis-benzylisoquinoline alkaloid isolated from the green seed embryos Nelumbo Nucifera Gaertn (Lotus) that displays multiple pharmacological activities including anti-tumor, antidepressant-like and antiarrhythmic actions. Recent studies shown that neferine potently inhibits proliferation of human osteosarcoma cells while is low-toxic on non-neoplastic human osteoblast cells. Apparently in U2OS cells, neferine stabilizes p21 through the activation of p38 MAPK, which leads to G1 cell cycle arrest. Also, neferine inhibits Ang II-induced HUVSMC proliferation by upregulation of HO-1.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000396758
0000396758
0000173885
0000173886
0000173886

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Shuaizeng Yin et al.
Journal of biochemical and molecular toxicology, 34(2), e22429-e22429 (2019-12-21)
Alzheimer's disease (AD) is an age-associated neurodegenerative disease, which is developed by oxidative stress and acetylcholine contraction in the synaptic cleft of the neurons. This leads to dementia, memory loss, and decrease in learning ability and orientation. In this research
Hyun Ah Jung et al.
Life sciences, 87(13-14), 420-430 (2010-08-26)
the multifunctional potential of neferine derived from the embryo of Nelumbo nucifera seeds for the age-related neurodegenerative disorders, in vivo anti-amnesic activities and in vitro cholinesterases (ChEs)- and β-site APP cleaving enzyme 1 (BACE1)-inhibitory activities, as well as anti-inflammatory and
Hui Ding et al.
European journal of pharmacology, 650(1), 163-169 (2010-10-26)
Neferine is a major alkaloid component of "Lian Zi Xin", embryos of the seeds of Nelumbo nucifera Gaertner, Nymphaeaceae. Previous studies have shown that neferine has an inhibitory effect on pulmonary fibrosis through its anti-inflammatory and anti-oxidative activities and inhibition
Yumi Sugimoto et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 15(12), 1117-1124 (2008-11-18)
The effects of embryos of the seeds of Nelumbo nucifera on the central nervous system were studied in mice. MeOH extracts of embryos of Nelumbo nucifera seeds significantly inhibited locomotor activity in mice. The MeOH extract was successively partitioned between
Juan Li et al.
Artificial cells, nanomedicine, and biotechnology, 48(1), 96-106 (2019-12-20)
The diabetic foot ulcer (DFU) may be associated with late healing and septic manifestation, subsequently lead to amputation which is an overpriced incident. Neferine is an alkaloid found lotus. Neferine possesses many physiological functions such as anti-inflammatory, antioxidant, antimicrobial activity
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