SML0036

Procarbazine hydrochloride

≥98% (HPLC)

• Sinónimos: N-(1-Methylethyl)-4-[(2-methylhydrazinyl)methyl]benzamide hydrochloride
• Fórmula empírica (notación de Hill): C₁₂H₁₉N₃O·HCl
• Número de CAS: 366-70-1
• Peso molecular: 257.76
• EC Number: 206-678-6
• MDL number: MFCD00072082
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825106
• NACRES: NA.77

Propiedades

• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: DMSO: ≥18 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.CNNCc1ccc(cc1)C(=O)NC(C)C
• InChI: 1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H
• InChI key: DERJYEZSLHIUKF-UHFFFAOYSA-N

Descripción

Application

Procarbazine hydrochloride has been used to study its physicochemical property.

Procarbazine, an antineoplastic alkylating agent, may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an anticancer agent. It may be used to study new combination of anticancer drugs.

Biochem/physiol Actions

Procarbazine is an antineoplastic alkylating agent widely used in cancer chemotherapy in combination with other compounds. It has multiple mechanisms of action. Procarbazine inhibits protein, RNA and DNA synthesis in addition to being an alkylating agent.

Procarbazine is metabolized to azoprocarbazine either by cytochrome P450 enzyme and monoamine oxidase in an NADPH (nicotinamide adenine diphosphate) dependent or independent manner. It is considered neurotoxic. Procarbazine is used in combination with therapy for treating Hodgkin′s disease.

Información de seguridad

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H341,H350,H360
• pcodes: P201 - P301 + P312 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Repr. 1A
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable