SML0022

IMB-10

≥98% (HPLC)

• Sinónimos: 3-(2-methylphenyl)-5-(3-phenyl-2-propen-1-ylidene)-2-thioxo-4-thiazolidinone
• Fórmula empírica (notación de Hill): C₁₉H₁₅NOS₂
• Número de CAS: 307525-40-2
• Peso molecular: 337.46
• MDL number: MFCD20134199
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825094
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: yellow
• solubility: DMSO: ≥25 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cc1ccccc1N2C(=S)S\C(=C\C=C\c3ccccc3)C2=O
• InChI: 1S/C19H15NOS2/c1-14-8-5-6-12-16(14)20-18(21)17(23-19(20)22)13-7-11-15-9-3-2-4-10-15/h2-13H,1H3/b11-7+,17-13+
• InChI key: UYZLENPCNZVWQZ-QHMSGILQSA-N

Descripción

Application

IMB-10 may be used to study integrin-mediated signaling in tumor cells.

Biochem/physiol Actions

IMB-10 is a ligand for the αMβ2 integrin that stabilizes the binding of the integrin to endogenous ligands such as proMMP-9 and fibrinogen. IMB-10 blocks migration of lymphocyte cell lines and inhibits leukocyte infiltration in a murine thioglycolate-induced peritonitis.

IMB-10 is a thioxothiazolidine compound that inhibits the infiltration of leukocytes to the site of tumor and blocks the invasion of HSC-3 carcinoma. It modulates the host inflammatory responses and tumor progression.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3